Zhu Jun, Liang Zhen, Song Yuxuan, Yang Yongjiao, Xu Yawei, Lu Yi, Hu Rui, Ou Ningjing, Zhang Wei, Liu Xiaoqiang
Urology Department, Tianjin Medical University General Hospital, Tianjin, China.
Urology Department, Second Hospital of Tianjin Medical University, Tianjin, China.
Andrologia. 2020 Nov;52(10):e13734. doi: 10.1111/and.13734. Epub 2020 Jul 1.
To assess the value of biparametric magnetic resonance imaging (bpMRI) for detecting and ruling out prostate cancer in patients with elevated prostate-specific antigen (PSA). The basic information and bpMRI images of enrolled patients who took transperineal template saturate biopsy were retrospectively collected for analysis. Based on our results, we found that free/total PSA, and PI-RADS score were independent risk factors of PCa (p < .05), the PSA density, PI-RADS score were the independent risk factors of csPCa (p < .05). PI-RADS score threshold of 3 could achieve the highest Yonder index for predicting PCa, and PI-RADS score threshold of 4 could achieve the highest Yonder index for predicting csPCa. Therefore, we draw a conclusion that PI-RADSv2 score-based bpMRI could diminish the unnecessary prostate biopsies in patients with elevated PSA when combined with other PSA-related indicators.
评估双参数磁共振成像（bpMRI）在检测和排除前列腺特异性抗原（PSA）升高患者前列腺癌方面的价值。回顾性收集接受经会阴模板饱和穿刺活检的入选患者的基本信息和bpMRI图像进行分析。根据我们的结果，发现游离/总PSA和PI-RADS评分是前列腺癌的独立危险因素（p < 0.05），PSA密度、PI-RADS评分是临床显著前列腺癌（csPCa）的独立危险因素（p < 0.05）。PI-RADS评分阈值为3时预测前列腺癌可获得最高的尤登指数，PI-RADS评分阈值为4时预测csPCa可获得最高的尤登指数。因此，我们得出结论，基于PI-RADSv2评分的bpMRI与其他PSA相关指标联合应用时，可减少PSA升高患者不必要的前列腺穿刺活检。
