The University of Edinburgh and NHS Lothian, Edinburgh, United Kingdom.
Kyushu University, Fukuoka, Japan, and Hiroshima University, Hiroshima, Japan.
Am J Intellect Dev Disabil. 2020 Jul 1;125(4):260-273. doi: 10.1352/1944-7558-125.4.260.
Small studies in Western populations report a high prevalence of obstructive sleep apnea (OSA) in adults with Down syndrome. To date, ethnic differences have not been explored. A questionnaire sent to 2,752 adults with Down syndrome aged ≥16 years in Scotland and Japan (789 valid responses) estimated OSA prevalence based on reported symptoms. Symptoms were common in both countries, with snoring (p = 0.001) and arousals (p = 0.04) more prevalent in Japan. Estimated OSA prevalence in adults with Down syndrome was similar in the two countries, and raised in comparison with the general adult population (19.6% in Scotland and 14.3% in Japan; p = 0.08), though BMI was a confounder. Identification and treatment of OSA is recommended in adults with Down syndrome, regardless of ethnicity.
西方人群的小型研究报告称，唐氏综合征成年人中阻塞性睡眠呼吸暂停（OSA）的患病率很高。迄今为止，尚未探讨种族差异。一项发给苏格兰和日本 2752 名年龄≥16 岁的唐氏综合征成年人的问卷（789 份有效回复）根据报告的症状估计了 OSA 的患病率。两国的症状都很常见，日本的打鼾（p=0.001）和觉醒（p=0.04）更为普遍。两国唐氏综合征成年人的 OSA 患病率相似，与普通成年人群相比有所增加（苏格兰为 19.6%，日本为 14.3%；p=0.08），但 BMI 是一个混杂因素。建议无论种族如何，都应对唐氏综合征成年人进行 OSA 的识别和治疗。
