Centre for Excellence in Nanobio Translational Research (CENTRE), Department of Pharmaceutical Technology, University College of Engineering, Anna University, BIT Campus, Tiruchirappalli, Tamilnadu, India.
Curr Pharm Des. 2020;26(36):4591-4600. doi: 10.2174/1381612826666200701203432.
The sequence of biochemical and cellular responses restoring the integrity of the subcutaneous tissue of the skin is termed as wound healing. Inflammatory cytokine suppression and inflammatory transduction cascades are the major targets for wound healing. Formulations for wound healing should promote neovascularization and angiogenic pathways by increasing the expression of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor. Medication used for wound healing promotes antiinflammatory associated with anti-bacterial action. In order to boost the effectiveness of current medical treatments, the cutting-edge nanotechnology offers many novel therapies. This review summarized and discussed wound healing, types of wounds, natural materials used for wound healing, metallic nanoparticles and current nano drug delivery systems used for wound healing with special emphasis on the angiogenesis role in the healing of wounds.
被称为伤口愈合的是一系列恢复皮肤皮下组织完整性的生化和细胞反应。抑制炎症细胞因子和炎症转导级联是伤口愈合的主要靶点。用于伤口愈合的制剂应通过增加血管内皮生长因子、成纤维细胞生长因子和血小板衍生生长因子的表达来促进新血管生成和血管生成途径。用于伤口愈合的药物通过促进抗炎作用和抗菌作用来促进伤口愈合。为了提高现有医疗方法的效果，前沿纳米技术提供了许多新的治疗方法。本综述总结和讨论了伤口愈合、伤口类型、用于伤口愈合的天然材料、金属纳米粒子以及当前用于伤口愈合的纳米药物输送系统，特别强调了血管生成在伤口愈合中的作用。
