Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin 300193, China.
Curr Pharm Des. 2020;26(34):4220-4233. doi: 10.2174/1381612826666200701212859.
The brain's response to ischemic injury is an acute and long-term inflammatory process. This process involves activation of resident cells (mainly microglia, hematogenous macrophages), production of proinflammatory mediators and infiltration of various proinflammatory cells (mainly neutrophils and lymphocytes). These cells play an essential role in ischemic brain tissue by releasing either proinflammatory or anti-inflammatory mediators at different time points. However, the exact pathogenesis of proinflammatory or anti-inflammatory genes in this process has not yet been elucidated. This review aims to investigate the inflammatory process of stroke, especially the role of proinflammatory and anti-inflammatory genes in the pathogenesis of stroke. We also summarize the current clinical trials of drugs that target the inflammatory mechanism for intervention.
大脑对缺血性损伤的反应是一个急性和长期的炎症过程。这个过程涉及到驻留细胞（主要是小胶质细胞、血源性巨噬细胞）的激活、促炎介质的产生以及各种促炎细胞（主要是中性粒细胞和淋巴细胞）的浸润。这些细胞通过在不同时间点释放促炎或抗炎介质，在缺血性脑组织中发挥重要作用。然而，这个过程中促炎或抗炎基因的确切发病机制尚未阐明。本综述旨在探讨卒中的炎症过程，特别是促炎和抗炎基因在卒中发病机制中的作用。我们还总结了目前针对炎症机制进行干预的药物临床试验。
