Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, 210009, China.
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China.
BMC Infect Dis. 2020 Jul 1;20(1):463. doi: 10.1186/s12879-020-05184-3.
Globally, tuberculosis (TB) remains the leading cause of death from a single infectious disease. TB treatment outcome is an important indicator for the effectiveness of a national TB control program. This study aimed to assess treatment outcomes of TB patients and its determinants in Batkhela, Khyber Pakhtunkhwa, Pakistan.
A retrospective cohort study was designed using all TB patients who were enrolled at District Head Quarter (DHQ) Hospital Batkhela, Pakistan, from January 2011 to December 2014. A binary logistic regression models were used to identify factors associated with successful TB treatment outcomes defined as the sum of cure and completed treatment.
A total of 515 TB patients were registered, of which 237 (46%) were males and 278 (53.98%) females. Of all patients, 234 (45.44%) were cured and 210 (40.77%) completed treatment. The overall treatment success rate was 444 (86.21%). Age 0-20 years (adjusted odds ratio, AOR = 3.47; 95% confidence interval, CI) = 1.54-7.81; P = 0.003), smear-positive pulmonary TB (AOR) = 3.58; 95% CI = 1.89-6.78; P = < 0.001), treatment category (AOR = 4.71; 95% CI = 1.17-18.97; P = 0.029), and year of enrollment 2012 (AOR = 6.26; 95% CI = 2.52-15.59; P = < 0.001) were significantly associated with successful treatment outcome.
The overall treatment success rate is satisfactory but still need to be improved to achieve the international targeted treatment outcome. Type of TB, age, treatment category, and year of enrollment were significantly associated with successful treatment outcomes.
在全球范围内，结核病（TB）仍然是单一传染病导致死亡的主要原因。结核病治疗结果是国家结核病控制规划有效性的重要指标。本研究旨在评估巴基斯坦开伯尔-普赫图赫瓦省巴塔克赫拉的结核病患者的治疗结果及其决定因素。
使用 2011 年 1 月至 2014 年 12 月在巴基斯坦巴塔克赫拉地区卫生署医院登记的所有结核病患者，设计了一项回顾性队列研究。使用二元逻辑回归模型确定与成功结核病治疗结果相关的因素，成功结核病治疗结果定义为治愈和完成治疗的总和。
共登记了 515 名结核病患者，其中 237 名（46%）为男性，278 名（53.98%）为女性。所有患者中，234 人治愈（45.44%），210 人完成治疗（40.77%）。总体治疗成功率为 444 人（86.21%）。0-20 岁年龄组（调整后的优势比，AOR=3.47；95%置信区间，CI=1.54-7.81；P=0.003）、痰涂片阳性肺结核（AOR=3.58；95%CI=1.89-6.78；P<0.001）、治疗类别（AOR=4.71；95%CI=1.17-18.97；P=0.029）和 2012 年入组年份（AOR=6.26；95%CI=2.52-15.59；P<0.001）与治疗结果显著相关。
总体治疗成功率令人满意，但仍需提高以实现国际目标治疗结果。结核病类型、年龄、治疗类别和入组年份与治疗结果显著相关。
