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自身免疫性肺含铁血黄素沉着症并发结节病：临床经过和粒细胞-巨噬细胞集落刺激因子自身抗体的血清水平。

Autoimmune Pulmonary Alveolar Proteinosis Complicated with Sarcoidosis: the Clinical Course and Serum Levels of Anti-granulocyte-macrophage colony-stimulating Factor Autoantibody.

机构信息

Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.

Department of Pathology, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.

出版信息

Intern Med. 2020 Oct 15;59(20):2539-2546. doi: 10.2169/internalmedicine.3853-19. Epub 2020 Jun 30.

DOI:10.2169/internalmedicine.3853-19
PMID:32611952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7662056/
Abstract

Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction due to anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody. We experienced 2 cases of APAP complicated with sarcoidosis in a 42-year-old woman and a 51-year-old man (age at the sarcoidosis diagnosis). APAP preceded sarcoidosis in the woman, and both diseases were diagnosed simultaneously in the man. Sarcoidosis lesions were observed in the lung, skin, and eyes, and the pathological findings of APAP were not marked at the diagnosis of sarcoidosis in either case. Low-grade positive serum anti-GM-CSF autoantibody was suspected to be correlated with the occurrence of sarcoidosis and resolution of APAP.

摘要

自身免疫性肺泡蛋白沉积症 (APAP) 是由抗粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 自身抗体引起的巨噬细胞功能障碍引起的。我们遇到了 2 例自身免疫性肺泡蛋白沉积症并发结节病的病例，分别为一名 42 岁女性和一名 51 岁男性（结节病诊断时的年龄）。女性的自身免疫性肺泡蛋白沉积症先于结节病，而男性则同时诊断出两种疾病。结节病病变发生在肺部、皮肤和眼睛，在这两种情况下，结节病诊断时的自身免疫性肺泡蛋白沉积症的病理发现都不明显。低度阳性血清抗 GM-CSF 自身抗体疑似与结节病的发生和自身免疫性肺泡蛋白沉积症的缓解有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb0c/7662056/9cf78037481f/1349-7235-59-2539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb0c/7662056/d2824a266142/1349-7235-59-2539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb0c/7662056/4f7b57872de3/1349-7235-59-2539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb0c/7662056/a9e8237ec140/1349-7235-59-2539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb0c/7662056/9cf78037481f/1349-7235-59-2539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb0c/7662056/d2824a266142/1349-7235-59-2539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb0c/7662056/4f7b57872de3/1349-7235-59-2539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb0c/7662056/a9e8237ec140/1349-7235-59-2539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb0c/7662056/9cf78037481f/1349-7235-59-2539-g004.jpg

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本文引用的文献

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Pulmonary alveolar proteinosis in adults: pathophysiology and clinical approach.成人肺泡蛋白沉积症：病理生理学和临床方法。
Lancet Respir Med. 2018 Jul;6(7):554-565. doi: 10.1016/S2213-2600(18)30043-2. Epub 2018 Feb 1.
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Elevated Serum Anti-GM-CSF Antibodies before the Onset of Autoimmune Pulmonary Alveolar Proteinosis in a Patient with Sarcoidosis and Systemic Sclerosis.
血清抗粒细胞-巨噬细胞集落刺激因子自身抗体在结节病和过敏性肺炎患者中的临床意义。
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结节病和系统性硬化症患者自身免疫性肺泡蛋白沉积症发病前血清抗GM-CSF抗体升高。
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Pulmonary alveolar proteinosis: another autoimmune disease associated with sarcoidosis?肺泡蛋白沉积症：另一种与结节病相关的自身免疫性疾病？
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