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结节病患者并发自身免疫性肺泡蛋白沉积症

Autoimmune pulmonary alveolar proteinosis in a patient with sarcoidosis.

作者信息

Tanaka Yuko, Shirai Toshihiro, Asada Kazuhiro, Muramatsu Aya, Katsumata Mineo, Suda Takafumi

机构信息

Department of Respiratory Medicine Shizuoka General Hospital Shizuoka Japan.

Department of Pathology Shizuoka General Hospital Shizuoka Japan.

出版信息

Clin Case Rep. 2019 Mar 2;7(4):731-734. doi: 10.1002/ccr3.2068. eCollection 2019 Apr.

DOI:10.1002/ccr3.2068
PMID:30997074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6452467/
Abstract

Steroids used to treat sarcoidosis may induce aPAP. The cooccurrence of sarcoidosis and autoimmune pulmonary alveolar proteinosis (aPAP) is rare. In this case, aPAP merged into sarcoidosis regardless of the disease state of sarcoidosis and improved naturally. When using steroids during sarcoidosis exacerbation, attention should be paid to aPAP relapse.

摘要

用于治疗结节病的类固醇可能会诱发肺泡蛋白沉积症（aPAP）。结节病与自身免疫性肺泡蛋白沉积症（aPAP）同时出现的情况很少见。在这种情况下，无论结节病的疾病状态如何，aPAP都合并入结节病并自然改善。在结节病加重期间使用类固醇时，应注意aPAP复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9793/6452467/cda63c483fd0/CCR3-7-731-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9793/6452467/fcb4528e6dc5/CCR3-7-731-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9793/6452467/f2fc92370169/CCR3-7-731-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9793/6452467/2dbc221b2b93/CCR3-7-731-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9793/6452467/cda63c483fd0/CCR3-7-731-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9793/6452467/fcb4528e6dc5/CCR3-7-731-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9793/6452467/f2fc92370169/CCR3-7-731-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9793/6452467/2dbc221b2b93/CCR3-7-731-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9793/6452467/cda63c483fd0/CCR3-7-731-g004.jpg

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本文引用的文献

1
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Tohoku J Exp Med. 2017 Sep;243(1):77-83. doi: 10.1620/tjem.243.77.
2
Pulmonary alveolar proteinosis: another autoimmune disease associated with sarcoidosis?肺泡蛋白沉积症：另一种与结节病相关的自身免疫性疾病？
Sarcoidosis Vasc Diffuse Lung Dis. 2016 Mar 29;33(1):90-4.
3
Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan.
血清抗粒细胞-巨噬细胞集落刺激因子自身抗体在结节病和过敏性肺炎患者中的临床意义。
Orphanet J Rare Dis. 2020 Sep 29;15(1):272. doi: 10.1186/s13023-020-01546-x.
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Autoimmune Pulmonary Alveolar Proteinosis Complicated with Sarcoidosis: the Clinical Course and Serum Levels of Anti-granulocyte-macrophage colony-stimulating Factor Autoantibody.自身免疫性肺含铁血黄素沉着症并发结节病：临床经过和粒细胞-巨噬细胞集落刺激因子自身抗体的血清水平。
Intern Med. 2020 Oct 15;59(20):2539-2546. doi: 10.2169/internalmedicine.3853-19. Epub 2020 Jun 30.
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Sarcoidosis.结节病
N Engl J Med. 2007 Nov 22;357(21):2153-65. doi: 10.1056/NEJMra071714.
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Pulmonary alveolar proteinosis: progress in the first 44 years.肺泡蛋白沉积症：前44年的进展
Am J Respir Crit Care Med. 2002 Jul 15;166(2):215-35. doi: 10.1164/rccm.2109105.
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Crazy-paving appearance at thin-section CT: spectrum of disease and pathologic findings.薄层CT上的铺路石样表现：疾病谱与病理表现
Radiology. 1999 Apr;211(1):155-60. doi: 10.1148/radiology.211.1.r99ap10155.