Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Japan.
Department of Diabetes and Endocrinology, Graduate School of Medicine, Gifu University, Japan.
Intern Med. 2020 Oct 1;59(19):2397-2403. doi: 10.2169/internalmedicine.4396-20. Epub 2020 Jun 30.
The selective arterial calcium stimulation test (SACST) is one of the most useful localization tests for insulinoma but can cause false-positive and/or unexpected multi arterial positive results that hamper clinical decisions. There are also several adverse effects, such as nausea and hypoglycemia, at the conventional dose (0.025 mEq/kg) of calcium injection. We herein report five consecutive insulinoma cases in which low-dose (0.005-0.007 mEq/kg) calcium injection for SACST led to successful insulinoma localization. No adverse effects of SACST were observed. In conclusion, a low-dose SACST can be a favorable option as an insulinoma localization test in terms of accuracy and safety.
选择性动脉钙刺激试验（SACST）是胰岛素瘤最有用的定位试验之一，但可能导致假阳性和/或意外的多动脉阳性结果，从而干扰临床决策。在常规剂量（0.025mEq/kg）的钙注射时，还存在一些不良反应，如恶心和低血糖。在此，我们报告了五例连续的胰岛素瘤病例，在这些病例中，SACST 的低剂量（0.005-0.007mEq/kg）钙注射导致了成功的胰岛素瘤定位。未观察到 SACST 的不良反应。总之，低剂量 SACST 在准确性和安全性方面可以作为胰岛素瘤定位试验的一个有利选择。
