Zewdie Kaleab Alemayehu, Ayza Muluken Altaye, Amare Tesfaye Bekalu, Yimer Ebrahim M
Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, Ethiopia.
Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Clin Ophthalmol. 2020 Jun 25;14:1741-1747. doi: 10.2147/OPTH.S258044. eCollection 2020.
Diabetic retinopathy (DR) is a retinal vascular disorder associated with both type 1 and type 2 diabetes mellitus (DM). It is characterized by specific loss of pericytes, which leads to an augmented blood vessel permeability, and development of new blood vessels (retinal neovascularization). Moreover, stiffening of eye membrane, inflammation, and apoptosis of endothelial cells also lead to damage of the blood-retinal barrier and blindness in most cases unless it's detected and managed early. Hence, this review was intended to assess the potential roles of Netrin-1 and -4 as new/alternative biomarkers and therapeutic options for DR. Netrin-1 and -4 have been the most known ligands and are well known for their role in neural guidance. DR has both neural and vascular components; therefore, biomarkers used for both neural and vascular retinal tissues are potentially important. According to different experimental and clinical studies, as compared to the normal groups, there was a significant increment in both retinal Netrin-1 and -4 mRNA and protein levels in the retinopathy groups. In addition, exogenous supplementation of these proteins is also used as a therapeutic agent for DR.
糖尿病视网膜病变（DR）是一种与1型和2型糖尿病（DM）相关的视网膜血管疾病。其特征是周细胞特异性缺失，这会导致血管通透性增加以及新生血管形成（视网膜新生血管化）。此外，眼膜硬化、炎症以及内皮细胞凋亡也会导致血视网膜屏障受损，在大多数情况下会导致失明，除非早期发现并进行治疗。因此，本综述旨在评估Netrin-1和Netrin-4作为糖尿病视网膜病变新的/替代生物标志物和治疗选择的潜在作用。Netrin-1和Netrin-4是最知名的配体，以其在神经导向中的作用而闻名。糖尿病视网膜病变具有神经和血管成分；因此，用于神经和血管视网膜组织的生物标志物可能很重要。根据不同的实验和临床研究，与正常组相比，视网膜病变组中视网膜Netrin-1和Netrin-4的mRNA和蛋白质水平均显著升高。此外，这些蛋白质的外源性补充也被用作糖尿病视网膜病变的治疗药物。
