Wang Ning, Min Jingxian, Wei Qiang, Tan Wanlong, Dang Qiang
Department of Radiotherapy, Nan Fang Hospital, Southern Medical University, Guangzhou City, Guangdong Province 510515, People's Republic of China.
Department of Oncology, Kanghua Hospital, Dongguan City, Guangdong Province 523000, People's Republic of China.
Onco Targets Ther. 2020 Jun 24;13:6011-6015. doi: 10.2147/OTT.S252822. eCollection 2020.
Male primary urethral urothelium carcinoma is a rare clinical case. Here, we detail a case of a 58-year-old man with primary urothelium carcinoma of the distal urethra treated in our hospital. The patient with a neoplasm inside the external urethral orifice for 2 years, which was previously diagnosed as condyloma acuminata, had received photodynamic therapy for 3 times, with initial symptoms of urinary stream bifurcation and dysuria. The exfoliative urine cytology showed negative. Cystoscopy showed a tumor growing around the distal urethra. Biopsy and immunohistochemistry revealed high-grade papillary urothelium carcinoma. The patient received partial urethrectomy, followed by urinary bladder irrigation chemotherapy with epirubicin postoperatively. The corpus spongiosum was invaded while the corpus cavernosa were not. Postoperative pathological examination showed high-grade invasive urothelium carcinoma. There is no evidence of tumor recurrence, metastasis or surgical complications during a 61-month follow-up period. Male primary urethral urothelium carcinoma is a rare clinical case with particular clinical and pathological characteristics. There are still no established treatment guidelines and should be studied further.
男性原发性尿道尿路上皮癌是一种罕见的临床病例。在此，我们详细介绍一例在我院接受治疗的58岁男性远端尿道原发性尿路上皮癌患者。该患者尿道口肿物2年，此前诊断为尖锐湿疣，接受过3次光动力治疗，最初症状为尿流分叉和排尿困难。脱落尿细胞学检查呈阴性。膀胱镜检查显示肿瘤生长在远端尿道周围。活检及免疫组化显示为高级别乳头状尿路上皮癌。患者接受了部分尿道切除术，术后用表柔比星进行膀胱灌注化疗。海绵体受累，而阴茎海绵体未受累。术后病理检查显示为高级别浸润性尿路上皮癌。在61个月的随访期内，无肿瘤复发、转移或手术并发症的证据。男性原发性尿道尿路上皮癌是一种具有特殊临床和病理特征的罕见临床病例。目前仍没有既定的治疗指南，应进一步研究。
