Vignoli Massimo, De Amicis Ippolito, Tamburro Roberto, Quaglione Gina, Salviato Nicoletta, Collivignarelli Francesco, Terragni Rossella, Pastrolin Stefano, Marruchella Giuseppe
Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
Human Pathology Unit, "Giuseppe Mazzini" Hospital, Piazza Italia, Teramo, Italy.
Front Vet Sci. 2020 Jun 16;7:337. doi: 10.3389/fvets.2020.00337. eCollection 2020.
Persistent Müllerian duct syndrome (PMDS), or uterus masculinus, is a rare autosomal recessive form of male pseudohermaphroditism due to the failure of paracrine anti-Müllerian hormone (AMH) secretion by Sertoli cells or failure of the Müllerian ducts to respond to AMH secretion. The malignant degeneration of persistent Müllerian remnants is rare. In human medicine, few related reports exist. In veterinary medicine, this is the first report describing adenocarcinoma of the uterus masculinus involving the prostate in a dog. An 11-year-old, male, neutered Pomeranian dog was referred for computed tomography due to the suspicion of prostatic carcinoma based on ultrasound and cytological examinations. The computed tomography findings were consistent with a uterus masculinus mass with possible prostatic infiltration. Uterus masculinus removal and total prostatectomy were performed; termino-terminal urethral anastomosis was carried out. Dehiscence of the anastomosis was observed 3 days after surgery. The owner declined any further procedures, and the dog was euthanized 5 days after surgery. Histopathological evaluation revealed adenocarcinoma of the uterus masculinus. Adenocarcinoma of the uterus masculinus may occur, suggesting that patients with PMDS should be evaluated for malignant changes of Müllerian remnants.
持续性苗勒管综合征（PMDS），又称男性子宫，是一种罕见的常染色体隐性遗传性男性假两性畸形，其病因是支持细胞旁分泌抗苗勒管激素（AMH）分泌失败或苗勒管对AMH分泌无反应。持续性苗勒管残余物的恶性变很少见。在人类医学中，相关报道很少。在兽医学中，这是首例描述犬男性子宫腺癌累及前列腺的报告。一只11岁的已绝育雄性博美犬因超声和细胞学检查怀疑患有前列腺癌而接受计算机断层扫描。计算机断层扫描结果与男性子宫肿物伴可能的前列腺浸润一致。进行了男性子宫切除和全前列腺切除术；进行了端端尿道吻合术。术后3天观察到吻合口裂开。主人拒绝进一步治疗，该犬在术后5天实施安乐死。组织病理学评估显示为男性子宫腺癌。男性子宫腺癌可能会发生，这表明对于持续性苗勒管综合征患者，应评估苗勒管残余物的恶性变化。
