Academic Unit of Child Health, University of Sheffield, Damer Street, Sheffield, S10 2TH, UK.
The Mellanby Centre for Bone Research, Academic Unit of Bone Metabolism, Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK.
Pediatr Radiol. 2020 Nov;50(12):1781-1787. doi: 10.1007/s00247-020-04736-8. Epub 2020 Jul 1.
Bone health in children with osteogenesis imperfecta is monitored using radiographs and dual-energy X-ray absorptiometry, which have limitations. High-resolution peripheral quantitative CT can non-invasively derive bone microarchitectural data. Children with severe osteogenesis imperfecta have fragile deformed bones, and positioning for this scan can be difficult. We assessed the feasibility of high-resolution peripheral quantitative CT in nine children aged 9-15 years with osteogenesis imperfecta and compared results with dual-energy X-ray absorptiometry and with healthy controls. All nine recruited children were successfully scanned and showed no preference for either modality. It therefore appears feasible to perform high-resolution peripheral quantitative CT in children with osteogenesis imperfecta aged 9 years and older. Future studies should focus on understanding the clinical implications of the technology in this patient cohort.
儿童成骨不全症的骨骼健康通过 X 射线和双能 X 射线吸收法进行监测，但这些方法都存在局限性。高分辨率外周定量 CT 可以非侵入性地获得骨微观结构数据。患有严重成骨不全症的儿童骨骼脆弱畸形，进行这种扫描的定位可能很困难。我们评估了高分辨率外周定量 CT 在 9 名 9-15 岁成骨不全症儿童中的可行性，并将结果与双能 X 射线吸收法和健康对照组进行了比较。所有 9 名入组的儿童都成功地进行了扫描，对两种方式都没有偏好。因此，对于 9 岁及以上的成骨不全症儿童，进行高分辨率外周定量 CT 似乎是可行的。未来的研究应重点关注理解该技术在该患者群体中的临床意义。
