Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California, USA.
Ann Neurol. 2020 Oct;88(4):851-854. doi: 10.1002/ana.25838. Epub 2020 Aug 6.
Many patients with severe coronavirus disease 2019 (COVID-19) remain unresponsive after surviving critical illness. Although several structural brain abnormalities have been described, their impact on brain function and implications for prognosis are unknown. Functional neuroimaging, which has prognostic significance, has yet to be explored in this population. Here we describe a patient with severe COVID-19 who, despite prolonged unresponsiveness and structural brain abnormalities, demonstrated intact functional network connectivity, and weeks later recovered the ability to follow commands. When prognosticating for survivors of severe COVID-19, clinicians should consider that brain networks may remain functionally intact despite structural injury and prolonged unresponsiveness. ANN NEUROL 2020;88:851-854.
许多患有严重 2019 冠状病毒病（COVID-19）的患者在度过重病期后仍没有反应。尽管已经描述了几种结构脑异常，但它们对脑功能的影响及其对预后的意义尚不清楚。具有预后意义的功能性神经影像学在该人群中尚未得到探索。在这里，我们描述了一名患有严重 COVID-19 的患者，尽管存在长时间的无反应和结构脑异常，但表现出完整的功能网络连接，几周后恢复了听从命令的能力。在预测严重 COVID-19 幸存者时，临床医生应考虑到，尽管存在结构损伤和长时间的无反应，大脑网络仍可能保持功能完整。ANN NEUROL 2020;88:851-854.
