Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU School of Medicine (S.B.B., M.C.K., J.S.M., D.A.K.).
Keenan Centre for Biomedical Research, Critical Care Department, St. Michael's Hospital, Toronto, Canada (A.H.J.).
Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2586-2597. doi: 10.1161/ATVBAHA.120.314515. Epub 2020 Sep 22.
The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions.
严重急性呼吸综合征冠状病毒 2 于 2019 年末作为一种严重的人类病原体出现，导致疾病 2019 年冠状病毒病（COVID-19）。严重 COVID-19 的最常见临床表现是符合急性呼吸窘迫综合征的急性呼吸衰竭。气道、肺实质、肺血管和呼吸神经肌肉疾病均为 COVID-19 的特征。本文综述了严重急性呼吸综合征冠状病毒 2 感染对呼吸系统不同部位的影响、对呼吸疾病潜在生物学的理解线索，以及突出了当前和未来的转化和临床研究问题。
