Baek Sanghoon, Kwon Jimin, Mano Taisei, Tokito Shizuo, Jung Sungjune
Department of Creative IT Engineering / Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, 37673, Republic of Korea.
Research Center for Organic Electronics (ROEL), Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
Macromol Biosci. 2020 Nov;20(11):e2000144. doi: 10.1002/mabi.202000144. Epub 2020 Jul 1.
Organic transistors are promising platforms for wearable biosensors. However, the strategies to improve signal amplification have yet to be determined, particularly regarding biosensors that generate very weak signals. In this study, an organic voltage amplifier is presented for a lactate sensor on flexible plastic foil. The preamplifier is based on a 3D complementary inverter, which is achieved by vertically stacking complementary transistors with a shared gate between them. The shared gate is extended and functionalized with a lactate oxidase enzyme to detect lactate. The sensing device successfully detects the lactate concentration in the human sweat range (20-60 mm) with high sensitivity (6.82 mV mm ) due to high gain of its amplification. The 3D integration process is cost-effective as it is solution-processable and doubles the number of transistors per unit area. The device presented in this study would pave the way for the development of high-gain noninvasive sweat lactate sensors that can be wearable.
有机晶体管是可穿戴生物传感器的理想平台。然而，提高信号放大的策略尚未确定，特别是对于产生非常微弱信号的生物传感器。在本研究中，提出了一种用于柔性塑料箔上乳酸传感器的有机电压放大器。前置放大器基于三维互补逆变器，它通过垂直堆叠互补晶体管并在它们之间共享一个栅极来实现。共享栅极通过乳酸氧化酶进行扩展和功能化以检测乳酸。由于其放大增益高，该传感装置能够以高灵敏度（6.82 mV/mm）成功检测人体汗液范围内（20 - 60 mM）的乳酸浓度。三维集成工艺具有成本效益，因为它可以通过溶液处理，并且使每单位面积的晶体管数量增加一倍。本研究中展示的器件将为可穿戴的高增益无创汗液乳酸传感器的开发铺平道路。
