School of Nursing, Institute of Health, Guangdong Pharmaceutical University, Guangzhou, China.
Department of Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
J Physiol Sci. 2021 Aug 26;71(1):26. doi: 10.1186/s12576-021-00811-3.
Sweat is a noninvasive biological fluid on the surface of human skin and has attracted increasing attention as a diagnostic specimen for disease and biomarker detection. Sweat metabolite quantification is possible due to progress in sweat analysis techniques; nevertheless, the role of sweat monitoring in energy metabolism, physiological or pathological state assessment, health status assessment, and the development and outcome of metabolism-related diseases remains unclear. This review provides a comprehensive overview of the literature on human sweat lactate concentration. The first, second, and third sections of this review present an introduction of sweat lactate, methods for the collection and storage of sweat lactate samples, and methods of detection and analysis of sweat lactate, respectively. The fourth section elaborates upon the current state of clinical application of sweat lactate monitoring and its prospects for health surveillance. The last section focuses on the challenges and future directions of this novel technology for detecting lactate in sweat.
汗液是人体皮肤表面的一种非侵入性生物流体，作为疾病诊断样本和生物标志物检测，越来越受到关注。由于汗液分析技术的进步，汗液代谢物的定量成为可能；然而，汗液监测在能量代谢、生理或病理状态评估、健康状况评估以及代谢相关疾病的发展和结局中的作用仍不清楚。本综述全面概述了有关人汗乳酸浓度的文献。本文的第一、二、三部分分别介绍了汗乳酸、汗乳酸样本的采集和储存方法以及汗乳酸的检测和分析方法。第四部分阐述了汗乳酸监测的临床应用现状及其在健康监测方面的前景。最后一部分重点讨论了这项检测汗液中乳酸的新技术所面临的挑战和未来发展方向。
