344933Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru-SP, Brazil.
Department of Genetic, 344933Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru-SP, Brazil.
Cleft Palate Craniofac J. 2021 Jan;58(1):78-83. doi: 10.1177/1055665620937499. Epub 2020 Jul 2.
The aim of this study was to compare the dentoskeletal pattern of Treacher Collins syndrome (TCS) and nonsyndromic Pierre Robin sequence (PRS).
Retrospective.
Single center.
Eighteen patients diagnosed with TCS (Group TCS) or PRS (Group PRS) in rehabilitation treatment at a single center. Group TCS was composed of 9 patients (4 male, 5 female) with a mean age of 12.9 years (standard deviation = 4.8). Group PRS was composed of 9 patients paired by age and sex with group TCS.
MAIN OUTCOME MEASURE(S): Cone beam computed tomography-derived cephalometric images taken before the orthodontic or the orthodontic-surgical treatment were analyzed using Dolphin Imaging (Dolphin Imaging 11.0 & Management Solutions). Variables evaluating the cranial base, the maxillary and mandibular skeletal components, maxillomandibular relationship, the vertical components and the dentoalveolar region were measured. Intergroup comparisons were performed using tests. The significance level considered was 5%.
Intergroup differences in the mandible size and growth pattern were observed. Group TCS showed a smaller mandibular length (Co-Go, Co-Gn) and a higher palatal plane (SN-Palatal Plane) and mandibular plane angles (SN-Go.Gn) compared to group PRS. No differences between TCS and PRS were observed for the sagittal position of the maxilla, maxillomandibular relationship, and dental components.
Treacher Collins syndrome presented a decreased mandible and a more severe vertical growth pattern compared to PRS.
本研究旨在比较特雷彻·柯林斯综合征（TCS）和非综合征性 Pierre Robin 序列（PRS）的牙颌面骨骼形态。
回顾性研究。
单中心。
在单个中心接受康复治疗的 18 名诊断为 TCS（TCS 组）或 PRS（PRS 组）的患者。TCS 组由 9 名患者（4 名男性，5 名女性）组成，平均年龄为 12.9 岁（标准差=4.8）。PRS 组由 9 名与 TCS 组年龄和性别相匹配的患者组成。
在正畸或正畸-正颌手术治疗前，使用 Dolphin Imaging（Dolphin Imaging 11.0 和管理解决方案）对锥形束计算机断层扫描获得的头影测量图像进行分析。评估颅底、上颌和下颌骨骼成分、上下颌骨关系、垂直成分和牙牙槽区域的变量。使用 t 检验进行组间比较。置信水平设为 5%。
观察到下颌大小和生长模式的组间差异。与 PRS 组相比，TCS 组下颌长度（Co-Go、Co-Gn）较小，腭平面（SN-Palatal Plane）和下颌平面角（SN-Go.Gn）较高。上颌的矢状位置、上下颌骨关系和牙齿成分在 TCS 和 PRS 之间无差异。
与 PRS 相比，TCS 表现为下颌骨减小和更严重的垂直生长模式。
