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碳离子治疗的 HIMM 用束流监测系统和质量保证设备的性能。

Performances of the beam monitoring system and quality assurance equipment for the HIMM of carbon-ion therapy.

机构信息

Beam diagnostic (BD) group, Instituted of modern physics, Chinese academic of science, Lanzhou, 730000, Chin.

出版信息

J Appl Clin Med Phys. 2020 Aug;21(8):289-298. doi: 10.1002/acm2.12916. Epub 2020 Jul 2.

Abstract

PURPOSE

The heavy-ion medical machine (HIMM), which is the first commercial medical accelerator designed and built independently by the institute of modern physics (IMP) in Wuwei, Gansu Province, China, had officially completed clinical trials at the time of this article's writing. Three types of detector systems were developed based on the ionization-chamber principle to monitor the beam parameters during treatment in real time, quickly verify the beam performance during a routine checkup, and ensure patient safety.

METHODS AND MATERIALS

The above-mentioned detector systems were used for beam monitoring and quality assurance in the treatment system. The beam-monitoring system is composed of three integral ionization chambers (ICs) and two multistrip ionization chambers (MSICs) as a redundant design. The irradiation dose, beam position, and homogeneity of a lateral profile are monitored online by the beam-monitoring system, and safety interlocks are established to keep the test results under the predefined tolerance limitation. The quality-assurance equipment was composed of one MSIC and one IC stack. The IC stack was used for energy verification.

RESULTS

The off-axis response of ICs is within a tolerance of 2%, and the dose interlock system (DIS) response time is less than 7 ms during the treatment process. The positioning resolution of MSICs reached 73 µm. The IC stack can verify the beam range within one spill and the measurement resolution is less than 0.2 mm.

CONCLUSIONS

The beam-monitoring system (BMS) and quality-assurance equipment (QAE) have been installed and run successfully within HIMM for two years and are associated with the HIMM treatment system to deliver the right dose to the correct position precisely. Furthermore, the daily QA task is simplified by it. Above all, the system has passed the performance test of the China Food and Drug Administration (CFDA).

摘要

目的

重离子医用设施(HIMM)是中国甘肃省武威市近代物理研究所自主设计和建造的首台商用医用加速器,截至本文撰写时,该设施已完成临床试验。为了在治疗过程中实时监测束流参数、在常规检查中快速验证束流性能并确保患者安全,基于电离室原理开发了三种探测器系统。

方法和材料

上述探测器系统用于治疗系统中的束流监测和质量保证。束流监测系统由三个整体电离室(IC)和两个多丝电离室(MSIC)组成,采用冗余设计。束流监测系统在线监测辐照剂量、束流位置和横向轮廓均匀性,并建立安全互锁,将测试结果保持在预定公差限制内。质量保证设备由一个 MSIC 和一个 IC 堆叠组成。IC 堆叠用于能量验证。

结果

IC 的离轴响应在 2%的容差范围内,在治疗过程中,剂量互锁系统(DIS)的响应时间小于 7ms。MSIC 的定位分辨率达到 73µm。IC 堆叠可以验证一个射束间隔内的束流范围,测量分辨率小于 0.2mm。

结论

束流监测系统(BMS)和质量保证设备(QAE)已在 HIMM 中成功安装和运行两年,并与 HIMM 治疗系统配合使用,将正确的剂量精确地输送到正确的位置。此外,它简化了日常 QA 任务。最重要的是,该系统已经通过了中国食品药品监督管理局(CFDA)的性能测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92de/7484831/0199691b1bcb/ACM2-21-289-g001.jpg

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