Mirandola Alfredo, Molinelli S, Vilches Freixas G, Mairani A, Gallio E, Panizza D, Russo S, Ciocca M, Donetti M, Magro G, Giordanengo S, Orecchia R
Fondazione CNAO, strada Campeggi 53, Pavia 27100, Italy.
INFN, Torino 10125, Italy and Fondazione CNAO, strada Campeggi 53, Pavia 27100, Italy.
Med Phys. 2015 Sep;42(9):5287-300. doi: 10.1118/1.4928397.
To describe the dosimetric commissioning and quality assurance (QA) of the actively scanned proton and carbon ion beams at the Italian National Center for Oncological Hadrontherapy.
The laterally integrated depth-dose-distributions (IDDs) were acquired with the PTW Peakfinder, a variable depth water column, equipped with two Bragg peak ionization chambers. fluka Monte Carlo code was used to generate the energy libraries, the IDDs in water, and the fragment spectra for carbon beams. EBT3 films were used for spot size measurements, beam position over the scan field, and homogeneity in 2D-fields. Beam monitor calibration was performed in terms of number of particles per monitor unit using both a Farmer-type and an Advanced Markus ionization chamber. The beam position at the isocenter, beam monitor calibration curve, dose constancy in the center of the spread-out-Bragg-peak, dose homogeneity in 2D-fields, beam energy, spot size, and spot position over the scan field are all checked on a daily basis for both protons and carbon ions and on all beam lines.
The simulated IDDs showed an excellent agreement with the measured experimental curves. The measured full width at half maximum (FWHM) of the pencil beam in air at the isocenter was energy-dependent for both particle species: in particular, for protons, the spot size ranged from 0.7 to 2.2 cm. For carbon ions, two sets of spot size are available: FWHM ranged from 0.4 to 0.8 cm (for the smaller spot size) and from 0.8 to 1.1 cm (for the larger one). The spot position was accurate to within ± 1 mm over the whole 20 × 20 cm(2) scan field; homogeneity in a uniform squared field was within ± 5% for both particle types at any energy. QA results exceeding tolerance levels were rarely found. In the reporting period, the machine downtime was around 6%, of which 4.5% was due to planned maintenance shutdowns.
After successful dosimetric beam commissioning, quality assurance measurements performed during a 24-month period show very stable beam characteristics, which are therefore suitable for performing safe and accurate patient treatments.
描述意大利国家肿瘤强子治疗中心主动扫描质子束和碳离子束的剂量学调试及质量保证(QA)情况。
使用配备两个布拉格峰电离室的PTW Peakfinder可变深度水柱获取横向积分深度剂量分布(IDDs)。利用fluka蒙特卡罗代码生成能量库、水中的IDDs以及碳离子束的碎片谱。使用EBT3胶片进行光斑尺寸测量、扫描野上的束流位置以及二维野的均匀性测量。使用Farmer型电离室和高级Markus电离室,根据每个监测单元的粒子数进行束流监测器校准。每天对质子束和碳离子束的所有束流线路检查等中心处的束流位置、束流监测器校准曲线、扩展布拉格峰中心的剂量稳定性、二维野的剂量均匀性、束流能量、光斑尺寸以及扫描野上的光斑位置。
模拟的IDDs与测量的实验曲线显示出极好的一致性。等中心处空气中笔形束的半高宽(FWHM)测量值对于两种粒子类型均与能量相关:特别是对于质子,光斑尺寸范围为0.7至2.2厘米。对于碳离子,有两组光斑尺寸:FWHM范围为0.4至0.8厘米(较小光斑尺寸)和0.8至1.1厘米(较大光斑尺寸)。在整个20×20平方厘米的扫描野上,光斑位置精确到±1毫米以内;两种粒子类型在任何能量下,均匀方形野内的均匀性均在±5%以内。很少发现质量保证结果超出公差水平。在报告期内,机器停机时间约为6%,其中4.5%是由于计划内的维护停机。
在成功进行剂量学束流调试后,在24个月期间进行的质量保证测量显示束流特性非常稳定,因此适合进行安全准确的患者治疗。