Department of Health Sciences (Dissal), University of Genoa , Genoa, Italy.
Hygiene Unit, IRCCS Policlinico San Martino Hospital , Genoa, Italy.
Hum Vaccin Immunother. 2021 Feb 1;17(2):575-579. doi: 10.1080/21645515.2020.1777058. Epub 2020 Jul 2.
We have evaluated the immunological response to Hepatitis B virus (HBV) booster vaccine dose in 129 adults with underlying diseases in comparison with 694 subjects at occupational risk of infection, who have previously completed the primary series and resulted with anti-HBs <10 mIU/mL. After booster dose, 60.5% of the patients with underlying diseases and 14.8% of the subjects at occupational risk resulted seronegative. By comparing two groups, rate of subjects with anamnestic response was higher in at occupational risk group respect to that at risk for medical conditions (OR: 5.99 [95%IC, 3.81-9.41], < .001). This difference was associated to gender (males/females: OR: 0.619 [95%IC, 0.421-0.910], = .015) and age (better response for younger people, = .011).
我们评估了 129 名患有基础疾病的成年人对乙型肝炎病毒（HBV）加强疫苗剂量的免疫反应，并与 694 名职业感染风险的受试者进行了比较，这些受试者之前已完成了基础系列疫苗接种，但抗-HBs <10 mIU/mL。加强疫苗接种后，60.5%的基础疾病患者和 14.8%的职业感染风险受试者血清学阴性。通过比较两组，职业感染风险组的有既往反应史的受试者比例高于患有基础疾病的风险组（OR：5.99 [95%CI，3.81-9.41]， < 0.001）。这种差异与性别（男性/女性：OR：0.619 [95%CI，0.421-0.910]， = 0.015）和年龄（年轻人反应更好， = 0.011）有关。
