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High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy.在进一步完成全程疫苗接种后，克服对乙肝疫苗无应答状态的可能性很高：意大利佛罗伦萨医护学生和工作者扩展研究的结果
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4
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Hum Vaccin Immunother. 2018 Feb 1;14(2):450-455. doi: 10.1080/21645515.2017.1398297. Epub 2017 Dec 19.
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The 2016 Lifetime Immunization Schedule, approved by the Italian scientific societies: A new paradigm to promote vaccination at all ages.2016 年终身免疫接种计划，获得意大利科学协会批准：在所有年龄段推广疫苗接种的新模式。
Hum Vaccin Immunother. 2017 Nov 2;13(11):2531-2537. doi: 10.1080/21645515.2017.1366394.
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Strategies and actions of multi-purpose health communication on vaccine preventable infectious diseases in order to increase vaccination coverage in the population: The ESCULAPIO project.为提高人群疫苗接种覆盖率，针对疫苗可预防传染病开展多用途健康传播的策略与行动：埃斯库拉皮奥项目
Hum Vaccin Immunother. 2017 Feb;13(2):369-375. doi: 10.1080/21645515.2017.1268008.
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Vaccine safety evaluation: Practical aspects in assessing benefits and risks.疫苗安全性评估：评估益处与风险的实际方面。
Vaccine. 2016 Dec 20;34(52):6672-6680. doi: 10.1016/j.vaccine.2016.10.039. Epub 2016 Nov 8.
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Induced immunity against hepatitis B virus.诱导的抗乙型肝炎病毒免疫力。
World J Hepatol. 2015 Jun 28;7(12):1660-70. doi: 10.4254/wjh.v7.i12.1660.
9
Is hemodialysis a reason for unresponsiveness to hepatitis B vaccine? Hepatitis B virus and dialysis therapy.血液透析是对乙肝疫苗无反应的一个原因吗？乙肝病毒与透析治疗。
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[The 2014 lifetime immunization schedule approved by the Italian scientific societies. Italian Society of Hygiene, Preventive Medicine, and Public Health. Italian Society of Pediatrics. Italian Federation of Pediatric Physicians. Italian Federation of General Medical Physicians. Arezzo Service of Legal Medicine].[意大利科学协会批准的2014年终身免疫接种计划。意大利卫生、预防医学与公共卫生协会。意大利儿科学会。意大利儿科医师联合会。意大利普通医学医师联合会。阿雷佐法医学服务处]
Epidemiol Prev. 2014 Nov-Dec;38(6 Suppl 2):131-46.

需要特别关注乙肝疫苗接种无应答者，包括医护人员、学生和慢性患者。

Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients.

机构信息

Department of Health Sciences, University of Florence , Florence, Italy.

Department of Experimental and Clinical Medicine, University of Florence , Florence, Italy.

出版信息

Hum Vaccin Immunother. 2021 Feb 1;17(2):580-582. doi: 10.1080/21645515.2020.1810495. Epub 2020 Dec 3.

DOI:10.1080/21645515.2020.1810495
PMID:33270480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7899626/
Abstract

Both our research and that published by Sticchi et al. on immunological memory against hepatitis B virus (HBV) in health-care workers (HCWs) vaccinated as infants or adolescents confirm that in those testing negative after the primary course, one additional (fourth) booster dose is able to elicit an anti-HBs response in >85% subjects. The fifth and the sixth doses further contribute substantially to a high overall response rate. The rate of subjects showing an anamnestic response after the booster dose was almost six-fold higher in HCWs compared to chronic patients. Since universal vaccination in Italy resulted in a significant decrease in HBV infections, special attention and testing should be addressed to those affected by chronic diseases.

摘要

我们的研究和 Sticchi 等人发表的关于乙型肝炎病毒 (HBV) 免疫记忆的研究都证实，在基础免疫疗程后检测为阴性的人群中，再接种一剂（第四剂）加强针可以使超过 85%的受试者产生抗-HBs 反应。第五剂和第六剂进一步大大提高了总体反应率。与慢性患者相比，加强针后出现回忆反应的受试者在 HCWs 中的比例几乎高出六倍。由于意大利的乙肝疫苗普遍接种导致 HBV 感染显著减少，因此应特别关注和检测患有慢性疾病的人群。