Department of Pharmacy, Kerala University of Health Sciences, Thrissur, Kerala, India.
Research center for Advanced Materials Science, King Khalid University, 61413 Abha, Saudi Arabia.
Curr Med Chem. 2021;28(15):2852-2886. doi: 10.2174/0929867327666200702151018.
COVID-19, a type of infection that emerged in Wuhan, has become a pandemic affecting people worldwide and is rapidly spreading and evolving. Day by day, the confirmed cases and deaths are increasing many folds. SARS-CoV-2 is a novel virus; therefore, limited data are available to curb the disease. Epidemiological approaches, such as isolation, quarantine, social distancing, lockdown, and curfew, are being employed to halt the spread of the disease. Individual and joint efforts all over the world are producing a wealth of data and information which are expected to produce therapeutic strategies against COVID-19. Current research focuses on the utilization of antiviral drugs, repurposing strategies, vaccine development, as well as basic to advanced research about the organism and the infection. The review focuses on its life cycle, targets, and possible therapeutic strategies, which can lead to further research and development of COVID-19 therapy.
新型冠状病毒肺炎（COVID-19），一种起源于武汉的传染病，已经成为一种影响全球人民的大流行病，并正在迅速传播和演变。每天，确诊病例和死亡人数都在成倍增加。SARS-CoV-2 是一种新型病毒；因此，遏制这种疾病的可用数据有限。正在采取流行病学方法，如隔离、检疫、社交距离、封锁和宵禁，以阻止疾病的传播。世界各地的个人和集体正在产生大量的数据和信息，预计这些数据和信息将产生针对 COVID-19 的治疗策略。目前的研究重点是利用抗病毒药物、重新利用策略、疫苗开发，以及关于该生物体和感染的基础到高级研究。本综述重点介绍其生命周期、靶点和可能的治疗策略，这可能会导致进一步研究和开发 COVID-19 治疗方法。
