State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, Guangdong, China; Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, Guangdong, China.
Microvasc Res. 2020 Sep;131:104033. doi: 10.1016/j.mvr.2020.104033. Epub 2020 Jun 29.
This study characterized conjunctival microvascular morphological and haemodynamic responses after anti-inflammatory treatment in dry eye (DE).
Twenty-five patients with moderate DE (17 females and 8 males aged 48 ± 16 years) who underwent anti-inflammatory therapy (0.1% fluorometholone) and 25 healthy subjects (20 females and 5 males aged 48 ± 17 years) recruited as controls were enrolled. The conjunctival blood flow rate (BFR), blood flow velocity (BFV) and vessel diameter were measured by functional slit-lamp biomicroscopy (FSLB). DE symptoms and signs were assessed. All measurements were performed at baseline and at 30 and 60 days after commencement of treatment.
At baseline, the conjunctival BFR, BFV, and vessel diameter were higher in the DE group than in the control group (p < 0.05). The BFR, BFV and corneal fluorescein staining (CFS) scores decreased at 60 days after therapy compared to at baseline and 30 days (all p < 0.05); Ocular surface diseases index (OSDI), the hyperaemia index (HI) and vessel diameters only showed significant decreases at 30 days. Moreover, significant increases in the noninvasive tear film break-up time (NI-BUT) and Schirmer I test score (ST) were observed. The CFS score correlated positively with BFV (r = 0.46), BFR (r = 0.58) and vessel diameter (r = 0.47).
This study characterized conjunctival microvascular responses to anti-inflammatory treatment in DE patients. The results suggest that conjunctival BFV and BFR can be used as dynamic markers for treatment efficacy in DE.
本研究旨在描述干眼症（DE）抗炎治疗后结膜微血管形态和血流动力学的变化。
共纳入 25 例接受抗炎治疗（0.1%氟米龙）的中度 DE 患者（17 名女性，8 名男性，年龄 48±16 岁）和 25 名健康对照者（20 名女性，5 名男性，年龄 48±17 岁）。采用功能型眼前节裂隙灯显微镜（FSLB）测量结膜血流速率（BFR）、血流速度（BFV）和血管直径。评估 DE 症状和体征。所有测量均在基线时以及治疗开始后 30 和 60 天进行。
基线时，DE 组的结膜 BFR、BFV 和血管直径均高于对照组（p<0.05）。治疗 60 天后，BFR、BFV 和角膜荧光素染色（CFS）评分均低于基线和 30 天（均 p<0.05）；眼表疾病指数（OSDI）、充血指数（HI）和血管直径仅在 30 天时显著下降。此外，非侵入性泪膜破裂时间（NI-BUT）和 Schirmer I 试验评分（ST）显著增加。CFS 评分与 BFV（r=0.46）、BFR（r=0.58）和血管直径（r=0.47）呈正相关。
本研究描述了 DE 患者结膜微血管对抗炎治疗的反应。结果表明，结膜 BFV 和 BFR 可作为 DE 治疗效果的动态标志物。
