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健康受试者结膜和视网膜的微循环。

Microcirculation in the conjunctiva and retina in healthy subjects.

作者信息

Shi Ce, Jiang Hong, Gameiro Giovana Rosa, Wang Jianhua

机构信息

1School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang China.

2Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 1638 NW 10th Avenue, McKnight Building - Room 202A, Miami, FL 33136 USA.

出版信息

Eye Vis (Lond). 2019 Apr 6;6:11. doi: 10.1186/s40662-019-0136-3. eCollection 2019.

DOI:10.1186/s40662-019-0136-3
PMID:30993144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6451216/
Abstract

BACKGROUND

The aim was to determine the relationship between bulbar conjunctival microcirculation and retinal microcirculation in a healthy population.

METHOD

A functional slit-lamp biomicroscope (FSLB) was used to measure blood flow velocity (BFV) and blood flow rate (BFR) in the conjunctiva while a retinal function imager (RFI) was used to measure macular BFV and BFR in the retina. One eye of each subject of 58 self-reported healthy subjects was imaged in the same session on the same day.

RESULTS

The mean BFV in the venules of the conjunctiva was 0.49 ± 0.13 mm/s, which was significantly slower than that in the retinal arterioles (3.71 ± 0.78 mm/s,  < 0.001) and retinal venules (2.98 ± 0.58 mm/s,  < 0.001). The BFR in the conjunctiva (0.09 nl/s) was also significantly lower than that in the retina (arterioles = 0.81 nl/s, venules = 0.68 nl/s, all  < 0.001). The BFVs and BFRs were not related between the conjunctiva and retina (r ranged from - 0.17 to - 0.05, all  > 0.05).

CONCLUSION

The microcirculation in the retina appeared to be different from that in the conjunctiva.

摘要

背景

目的是确定健康人群中球结膜微循环与视网膜微循环之间的关系。

方法

使用功能性裂隙灯生物显微镜(FSLB)测量结膜中的血流速度(BFV)和血流量(BFR),同时使用视网膜功能成像仪(RFI)测量视网膜中黄斑的BFV和BFR。在同一天的同一时段对58名自我报告健康的受试者的一只眼睛进行成像。

结果

结膜小静脉中的平均BFV为0.49±0.13mm/s,明显慢于视网膜小动脉(3.71±0.78mm/s,<0.001)和视网膜小静脉(2.98±0.58mm/s,<0.001)中的BFV。结膜中的BFR(0.09nl/s)也明显低于视网膜中的BFR(小动脉=0.81nl/s,小静脉=0.68nl/s,均<0.001)。结膜和视网膜之间的BFV和BFR不相关(r范围为-0.17至-0.05,均>0.05)。

结论

视网膜中的微循环似乎与结膜中的不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c647/6451216/e69c402737e2/40662_2019_136_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c647/6451216/ed5319f309db/40662_2019_136_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c647/6451216/f7cc15f66720/40662_2019_136_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c647/6451216/c0a1cf199953/40662_2019_136_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c647/6451216/e69c402737e2/40662_2019_136_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c647/6451216/ed5319f309db/40662_2019_136_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c647/6451216/f7cc15f66720/40662_2019_136_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c647/6451216/c0a1cf199953/40662_2019_136_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c647/6451216/e69c402737e2/40662_2019_136_Fig4_HTML.jpg

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本文引用的文献

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3
Impaired retinal microcirculation in patients with Alzheimer's disease.阿尔茨海默病患者视网膜微循环受损。
奥可明®给药后,伴有 MTHFR 多态性的糖尿病视网膜病变患者的眼结合膜微循环得到改善。
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PLoS One. 2018 Feb 2;13(2):e0192154. doi: 10.1371/journal.pone.0192154. eCollection 2018.
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A Mini Review of Clinical and Research Applications of the Retinal Function Imager.视网膜功能成像仪的临床与研究应用综述
Curr Eye Res. 2018 Mar;43(3):273-288. doi: 10.1080/02713683.2017.1414853. Epub 2018 Jan 8.
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Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease.轻度认知障碍和阿尔茨海默病的黄斑微血管改变。
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