Khamesipour Ali, Molaei Soheila, Babaei-Pouya Navid, Moradi-Asl Eslam
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Deputy of Research&Technology, Ardabil University of Medical Sciences, Ardabil, Iran.
Korean J Parasitol. 2020 Jun;58(3):229-236. doi: 10.3347/kjp.2020.58.3.229. Epub 2020 Jun 26.
Cutaneous leishmaniosis (CL) is the most common form of leishmaniasis.CL caused by L. major and L. tropica is endemic in 17 provinces of Iran. This study was carried out to elucidate situation of CL in Ardabil province and to predict distribution of Phlebotomus papatasi and Phlebotomus sergenti (Diptera: Psychodidae) as vectors of CL in the region. In this cross-sectional study, data on CL patients were collected from local health centers of Ardabil province, Iran during 2006-2018 to establish a geodatabase using ArcGIS10.3. A total of 20 CL cases were selected randomly and skin samples were collected and analyzed by PCR method. MaxEnt 3.3.3 model was used to determine ecologically suitable niches for the main vectors. A total, 309 CL human cases were reported and the highest incidence rate of disease was occurred in Bilasavar (37/100,000) and Germi (35/100,000). A total of 2,794 sand flies were collected during May to October 2018. The environmentally suitable habitats for P. papatasi and P. sergenti were predicted to be present in northern and central areas of Ardabil province. The most variable that contributed ratio in the modeling were Isothermality and slope factors. Ardabil province is possibly an endemic are for CL. The presence of P. papatasi and P. sergenti justifies local transmission while the vectors of CL are existing in the northern and central areas of the province.
皮肤利什曼病（CL）是利什曼病最常见的形式。由硕大利什曼原虫和热带利什曼原虫引起的CL在伊朗17个省份呈地方性流行。本研究旨在阐明阿尔达比勒省CL的情况，并预测该地区作为CL传播媒介的巴氏白蛉和塞尔吉白蛉（双翅目：蛾蠓科）的分布。在这项横断面研究中，2006年至2018年期间从伊朗阿尔达比勒省的当地卫生中心收集CL患者的数据，使用ArcGIS10.3建立地理数据库。随机选择20例CL病例，采集皮肤样本并通过PCR方法进行分析。使用MaxEnt 3.3.3模型确定主要传播媒介在生态上适宜的栖息地。共报告了309例CL人类病例，疾病发病率最高的是比拉萨瓦尔（37/100,000）和杰尔米（35/100,000）。2018年5月至10月共收集到2794只白蛉。预计阿尔达比勒省北部和中部地区存在适合巴氏白蛉和塞尔吉白蛉生存的环境栖息地。在建模中贡献率变化最大的因素是等温性和坡度因子。阿尔达比勒省可能是CL的地方性流行区。巴氏白蛉和塞尔吉白蛉的存在证明了当地存在传播，因为该省北部和中部地区存在CL的传播媒介。
