费尔蒂综合征中的补体C4B无效等位基因。

Complement C4B-null alleles in Felty's syndrome.

作者信息

Thomson W, Sanders P A, Davis M, Davidson J, Dyer P A, Grennan D M

机构信息

University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford, United Kingdom.

出版信息

Arthritis Rheum. 1988 Aug;31(8):984-9. doi: 10.1002/art.1780310807.

DOI:10.1002/art.1780310807

PMID:3261591

Abstract

C4A and C4B allotypes were compared in 20 patients with Felty's syndrome (FS), 52 patients with rheumatoid arthritis (RA), and 55 control subjects. Nineteen of the FS patients had HLA-DR4. A C4B-null allele was more frequent in the patients with FS (60%) than in either the RA patients (15%) or the control subjects (26%). Only the differences between patients with FS and those with RA remained statistically significant when DR4 positive subjects were compared. The C4B null allele may identify individuals within the rheumatoid population who are at risk of developing particular systemic complications.

摘要

对20例费尔蒂综合征（FS）患者、52例类风湿关节炎（RA）患者和55名对照者的C4A和C4B同种异型进行了比较。19例FS患者携带HLA - DR4。FS患者中C4B无效等位基因的频率（60%）高于RA患者（15%）或对照者（26%）。当比较DR4阳性受试者时，只有FS患者与RA患者之间的差异具有统计学意义。C4B无效等位基因可能有助于识别类风湿人群中具有发生特定全身并发症风险的个体。