Paimela L, Leirisalo-Repo M, Lokki M L, Koskimies S
Department of Rheumatology, Helsinki City Hospital, Finland.
Clin Rheumatol. 1996 Nov;15(6):594-8. doi: 10.1007/BF02238550.
The prognostic significance of class III major histocompatibility complex complement components, factor B (Bf), C4A and C4B, were studied in a 3-year prospective study of 73 patients with early RA. Patients with C4B null allele had higher disease activity with more radiological progression than patients with C4A null allele or patients without null allele. C4B null allele also associated with increased susceptibility to side effects from antirheumatic treatment. The Bf phenotypes did not associate with the severity of RA. C4B null allele may have prognostic significance in determining a special subgroup of RA patients with a more complicated course of the disease.
在一项对73例早期类风湿关节炎（RA）患者进行的为期3年的前瞻性研究中，研究了Ⅲ类主要组织相容性复合体补体成分B因子（Bf）、C4A和C4B的预后意义。与具有C4A无效等位基因的患者或无无效等位基因的患者相比，具有C4B无效等位基因的患者疾病活动度更高，放射学进展更多。C4B无效等位基因还与抗风湿治疗副作用易感性增加相关。Bf表型与RA的严重程度无关。C4B无效等位基因在确定疾病病程更复杂的特殊RA患者亚组中可能具有预后意义。
