Liu Dongming, Xu Hongwei, Yi Fang
Department of Geriatric Neurology,Xiangya Hospital,Central South University,Changsha 410008,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Jun 30;42(3):417-420. doi: 10.3881/j.issn.1000-503X.11472.
Cryptococcal encephalitis is a fatal central nervous system infectious disease,whereas anti-N-methyl-D-aspartate(NMDA)receptor encephalitis(NMDARE)is an autoimmune syndrome associated with psychological symptoms,behavioural abnormalities,seizures,and dyskinesias.Despite their distinct pathologies and pathogenic mechanisms,both of them can lead to cognitive dysfunction and abnormal behaviors,although anti-NMDARE can also have mood and mental disorders as its core manifestations.A patient with nephrotic syndrome accompanied by both cryptococcal encephalitis and anti-NMDARE was treated in our center,which for the first confirmed that these two conditions could coexist in one patient.The underlying mechanism may be similar to that of anti-NMDARE after other infections.
隐球菌性脑炎是一种致命的中枢神经系统感染性疾病，而抗N-甲基-D-天冬氨酸（NMDA）受体脑炎（NMDARE）是一种与心理症状、行为异常、癫痫发作和运动障碍相关的自身免疫综合征。尽管它们的病理和致病机制不同，但两者均可导致认知功能障碍和异常行为，不过抗NMDARE也可将情绪和精神障碍作为其核心表现。我们中心收治了一名患有肾病综合征并伴有隐球菌性脑炎和抗NMDARE的患者，这首次证实了这两种病症可在同一患者中共存。其潜在机制可能与其他感染后抗NMDARE的机制相似。
