Hosseini Saeed Malek, Gholijani Naser, Chenari Nooshafarin, Kalantar Kurosh
Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
An Bras Dermatol. 2020 Sep-Oct;95(5):570-574. doi: 10.1016/j.abd.2020.02.005. Epub 2020 Jun 16.
Vitiligo is a common skin disorder in which melanocytes are destroyed by auto-reactive immune responses. The loss of melanocytes results in the appearance of depigmented areas in different parts of the body. Cytokines have remarkable roles in the pathogenesis of vitiligo, such as IL-1, IL-6, and TNF-α; interleukin 27 (IL-27) is a new member of the IL-6/IL-12 family, mainly released by activated antigen-presenting cells. IL-27 has been suggested to function as a pro-inflammatory as well as an anti-inflammatory cytokine. Altered concentrations of IL-27 have been shown in various auto-immune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis. No studies have been conducted to determine the expression of this cytokine in vitiligo patients.
The objective of this study was to determine the serum concentration of IL-27 in vitiligo patients and compare it with normal individuals.
The serum concentration of IL-27 in 79 vitiligo patients was evaluated in comparison to 45 healthy controls using ELISA assay.
Results showed decreased concentration of IL-27 in vitiligo patients as compared with healthy subjects (p=0.026). Furthermore, no correlation between IL-27 concentrations and disease parameters such as vitiligo severity and the extension of the depigmented area was observed.
A larger sample size would be more recommended for this study.
The reduction in the serum levels of IL-27 in vitiligo patients compared to normal subjects suggested the possible anti-inflammatory role of this cytokine in vitiligo. Thus, IL-27 may be considered as a new target for the manipulation of the immune system in vitiligo patients.
白癜风是一种常见的皮肤疾病，其中黑素细胞被自身反应性免疫反应破坏。黑素细胞的丧失导致身体不同部位出现色素脱失区域。细胞因子在白癜风的发病机制中具有显著作用，如白细胞介素-1（IL-1）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）；白细胞介素27（IL-27）是IL-6/IL-12家族的新成员，主要由活化的抗原呈递细胞释放。IL-27已被认为具有促炎和抗炎细胞因子的功能。在各种自身免疫性疾病如多发性硬化症、类风湿性关节炎和银屑病中，已显示IL-27浓度发生改变。尚未进行研究以确定该细胞因子在白癜风患者中的表达。
本研究的目的是确定白癜风患者血清中IL-27的浓度，并与正常个体进行比较。
使用酶联免疫吸附测定法（ELISA）评估79例白癜风患者血清中IL-27的浓度，并与45例健康对照进行比较。
结果显示，与健康受试者相比，白癜风患者中IL-27浓度降低（p = 0.026）。此外，未观察到IL-27浓度与疾病参数如白癜风严重程度和色素脱失区域范围之间的相关性。
本研究更建议采用更大的样本量。
与正常受试者相比，白癜风患者血清中IL-27水平降低，提示该细胞因子在白癜风中可能具有抗炎作用。因此，IL-27可被视为白癜风患者免疫系统调控的新靶点。
