Department of Hygiene and Epidemiology, Medical University of Lublin, Chodźki 7 Street, 20-093 Lublin, Poland.
Department of Dermatology, Venerology and Pediatric Dermatology, Independent Public Healthcare Unit No.1 in Lublin, Staszica 16 Street, 20-081 Lublin, Poland.
Biomed Pharmacother. 2023 Apr;160:114364. doi: 10.1016/j.biopha.2023.114364. Epub 2023 Feb 3.
Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. Variety of inflammatory mediators participate in the regulation of melanogenesis in melanocytes: interleukin-18 (IL-18), interleukin-33, granulocyte-macrophage colony stimulating factor, interferon-γ, prostaglandin E2 have the effect of promoting melanogenesis, while interleukin-1 (IL-1), interleukin-4, interleukin-6, interleukin-17 and tumor necrosis factor can inhibit melanogenesis.
Evaluation of IL-1α and IL-18 levels in peripheral blood in patients with vitiligo compared to healthy controls.
Fifty patients aged 18-81 with vitiligo participated in the study. The control group consisted of 38 healthy people. Venous blood samples were obtained from each participant. Serum IL-1α and IL-18 concentrations were determined using the enzyme-linked immunoabsorbent assay (ELISA).
Among patients with vitiligo, the mean concentration of IL-1α was 0.13 (± 0.535) pg/mL, while in the control group it was 0.51 (± 1.51). There were no statistically significant differences in IL-1α concentrations between patients in the study group compared to the control group (p > 0.05). In the study group, the mean IL-18 concentration was 141.05 (± 136.33) pg/mL vs 137.33 (± 105.83) pg/mL in the controls. There were no statistically significant differences in IL-18 concentrations between patients in the study group compared to the controls (p > 0.05). In the Spearman correlation test, no correlation was confirmed between IL1α and IL-18 concentrations in the group of patients with vitiligo vs healthy people.
There is no correlation between Il-1 and Il-18 concentration in the blood sera of patients with vitiligo.
白癜风是一种色素减退性疾病，其特征是皮肤中功能性黑素细胞丧失。多种炎症介质参与黑素细胞中黑素生成的调节：白细胞介素-18（IL-18）、白细胞介素-33、粒细胞-巨噬细胞集落刺激因子、干扰素-γ、前列腺素 E2 具有促进黑素生成的作用，而白细胞介素-1（IL-1）、白细胞介素-4、白细胞介素-6、白细胞介素-17 和肿瘤坏死因子可抑制黑素生成。
评估白癜风患者外周血中白细胞介素-1α（IL-1α）和白细胞介素-18（IL-18）水平与健康对照组相比的变化。
本研究纳入了 50 名年龄在 18-81 岁之间的白癜风患者。对照组由 38 名健康人组成。从每位参与者采集静脉血样本。使用酶联免疫吸附试验（ELISA）测定血清中 IL-1α 和 IL-18 浓度。
在白癜风患者中，IL-1α 的平均浓度为 0.13（±0.535）pg/mL，而对照组为 0.51（±1.51）pg/mL。研究组患者与对照组之间的 IL-1α 浓度无统计学差异（p>0.05）。在研究组中，IL-18 的平均浓度为 141.05（±136.33）pg/mL，而对照组为 137.33（±105.83）pg/mL。研究组患者与对照组之间的 IL-18 浓度无统计学差异（p>0.05）。在 Spearman 相关检验中，未在白癜风患者组与健康人群组中证实 IL1α 与 IL-18 浓度之间存在相关性。
白癜风患者血清中 Il-1 和 Il-18 浓度之间无相关性。
