新鲜阴道毛滴虫分离株对月经血和宫颈黏液中补体的敏感性差异
Differential susceptibility of fresh Trichomonas vaginalis isolates to complement in menstrual blood and cervical mucus.
作者信息
Demes P, Gombosová A, Valent M, Jánoska A, Fabusová H, Petrenko M
机构信息
Institute of Parasitology, Comenius University, Bratislava, Czechoslovakia.
出版信息
Genitourin Med. 1988 Jun;64(3):176-9. doi: 10.1136/sti.64.3.176.
The ability of complement in human menstrual blood and cervical mucus to kill Trichomonas vaginalis was compared with that of complement in serum, and 95 fresh trichomonal isolates obtained from vaginal wash material were evaluated for susceptibility to complement immediately after isolation. Only serum and menstrual blood with haemolytic activity produced total cytolysis of T vaginalis. The cytolytic abilities of these fluids were totally inactivated by treatment with heat or edetic acid (EDTA), which confirms the role of complement in cytolysis. Most cervical mucus samples had no detectable trichomonal cytotoxic properties. The cytotoxic activity in the remaining samples was not due to complement, as it was heat stable. Fresh isolates of T vaginalis and subpopulations of fresh isolates differed in their susceptibility or resistance to complement mediated lysis in serum. Resistance to complement did not remain stable after trichomonads were grown in vitro.
将人月经血和宫颈黏液中补体杀灭阴道毛滴虫的能力与血清中补体的能力进行了比较，并对从阴道冲洗液中获得的95株新鲜阴道毛滴虫分离株在分离后立即评估其对补体的敏感性。只有具有溶血活性的血清和月经血能使阴道毛滴虫完全细胞溶解。这些液体的细胞溶解能力经加热或依地酸（EDTA）处理后完全失活，这证实了补体在细胞溶解中的作用。大多数宫颈黏液样本未检测到滴虫细胞毒性特性。其余样本中的细胞毒性活性并非由补体引起，因为它对热稳定。新鲜的阴道毛滴虫分离株和新鲜分离株的亚群对血清中补体介导的裂解的敏感性或抗性不同。阴道毛滴虫在体外培养后对补体的抗性并不稳定。
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