Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Am J Dermatopathol. 2020 Dec;42(12):967-971. doi: 10.1097/DAD.0000000000001730.
Adenoid cystic carcinoma (ACC) is most commonly seen in the salivary glands but may occur at other sites. Primary or metastatic involvement of the skin is unusual. We report 2 cases of ACC with unusual presentation. In the first case, a 55-year-old woman presented with a cutaneous lesion on the right shin, and final pathology showed ACC. An extracutaneous origin was excluded by clinical and imaging studies. In the second case, a 49-year-old woman presented with a nodule on the breast, and biopsy confirmed high-grade ACC (>30% solid areas). She underwent lumpectomy and subsequent mastectomy after recurrence. Sixteen months after the initial diagnosis of ACC of the breast, distant metastases at multiple sites, including the skin, were identified. This report will increase awareness of these rare presentations of cutaneous ACC and allow correct diagnosis and appropriate management of such cases.
腺样囊性癌（ACC）最常见于唾液腺，但也可能发生在其他部位。皮肤的原发性或转移性受累并不常见。我们报告 2 例具有不常见表现的 ACC 病例。在第一个病例中，一名 55 岁女性右小腿出现皮肤病变，最终病理显示为 ACC。通过临床和影像学研究排除了皮肤外起源。在第二个病例中，一名 49 岁女性乳房出现结节，活检证实为高级别 ACC（>30%实性区域）。她在复发后接受了肿块切除术和随后的乳房切除术。在最初诊断为乳腺 ACC 后 16 个月，在多个部位（包括皮肤）发现远处转移。本报告将提高对这些罕见皮肤 ACC 表现的认识，并有助于正确诊断和适当管理此类病例。
