Shaffer D, Diflo T, Love W, Clowes G H, Maki T, Monaco A P
Department of Surgery, New England Deaconess Hospital, Boston, MA 02215.
Surgery. 1988 Sep;104(3):518-24.
We compared the immunologic and metabolic effects of systemic (i.e., caval) versus portal venous drainage of small-intestinal allografts in rats. Survival times in either unidirectional rejection or graft-versus-host disease models were not significantly altered by the route of venous drainage. Portoportal and portacaval isografts and controls were then pair-fed after transplantation. After 6 weeks of pair-feeding, weight gain, plasma amino acid concentration, and the histologic appearance of the liver were similar among the three groups. Hepatic protein synthesis was greater in pair-fed rats with portoportal isografts, although this difference disappeared in the fasted state. Our data suggest that there is little immunologic or metabolic advantage of portal versus systemic venous drainage of small-intestinal allografts in rats. Because the latter is technically simpler, it may be preferable in small-bowel transplantation.
我们比较了大鼠小肠同种异体移植物经全身（即腔静脉）与门静脉引流的免疫和代谢效应。在单向排斥或移植物抗宿主病模型中，静脉引流途径并未显著改变存活时间。然后，对门-门和门-腔同种异体移植组及对照组在移植后进行配对喂养。配对喂养6周后，三组之间的体重增加、血浆氨基酸浓度及肝脏组织学表现相似。门-门同种异体移植的配对喂养大鼠肝脏蛋白质合成较多，尽管这种差异在禁食状态下消失。我们的数据表明，大鼠小肠同种异体移植物经门静脉与全身静脉引流在免疫或代谢方面几乎没有优势。由于后者在技术上更简单，在小肠移植中可能更可取。
