在FK 506免疫抑制下的儿童小肠移植
Intestinal transplantation in children under FK 506 immunosuppression.
作者信息
Tzakis A G, Todo S, Reyes J, Nour B, Abu-Elmagd K, Selby R, Casavilla A, Kocoshis S, Demetris A J, Yunis E
机构信息
Department of Surgery, University of Pittsburgh, PA 15213.
出版信息
J Pediatr Surg. 1993 Aug;28(8):1040-3. doi: 10.1016/0022-3468(93)90514-l.
Intestinal transplantation, solitary (n = 3) or in combination with the liver (n = 7), was performed in 10 pediatric patients with intestinal failure. The liver was only replaced if there was liver failure and portal hypertension. Immunosuppression was based on FK 506. Two patients died, one of graft-versus-host disease and one of lymphoproliferative disease. One patient as still in the intensive care unit 1 month posttransplantation due to perioperative complications. The function of the intestinal grafts in the remaining patients is normal. All nutrition and medications including immunosuppression are being administered enterally. This series indicates that small bowel transplantation, alone or in combination with the liver, is feasible in pediatric patients.
对10例肠衰竭患儿实施了肠移植，其中孤立性肠移植3例，肠肝联合移植7例。仅在存在肝衰竭和门静脉高压时才进行肝脏置换。免疫抑制采用FK 506。2例患者死亡，1例死于移植物抗宿主病，1例死于淋巴增殖性疾病。1例患者在移植后1个月因围手术期并发症仍在重症监护室。其余患者的肠移植物功能正常。所有营养物质和药物（包括免疫抑制剂）均通过肠道给予。该系列研究表明，小肠移植单独或联合肝脏移植在儿科患者中是可行的。
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