基于碱基编码的四联体寡聚物的序列导向动态共价组装。

Sequence-directed dynamic covalent assembly of base-4-encoded oligomers.

机构信息

Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA and Department of Chemical Engineering, Monash University, Clayton, VIC 3800, Australia.

出版信息

Chem Commun (Camb). 2020 Jul 14;56(56):7817-7820. doi: 10.1039/d0cc01083a.

DOI:10.1039/d0cc01083a

PMID:32618971

Abstract

As an information-bearing biomacromolecule, DNA is encoded in base-4, where each residue site can be occupied by any one of four nucleobases. Mimicking the information dense, sequence-selective hybridization of DNA, we demonstrate two orthogonal dynamic covalent interactions to effect the selective assembly of molecular ladders and grids from base-4-encoded oligo(peptoid)s.

摘要

作为一种信息承载生物大分子，DNA 以碱基 4 编码，其中每个残基位点可以被四个碱基中的任意一个占据。模拟 DNA 密集的、序列选择性的杂交，我们展示了两种正交的动态共价相互作用，以从碱基 4 编码的寡肽中有效地选择性组装分子梯和网格。