Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Division of Hematology and Medical Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
J Chemother. 2021 Apr;33(2):116-121. doi: 10.1080/1120009X.2020.1785740. Epub 2020 Jul 3.
Docetaxel is an anti-microtubule agent and a highly effective treatment of locally advanced and metastatic breast cancer. There are several adverse effects associated with docetaxel, such as myelosuppression, peripheral neuropathy, fluid retention, and asthenia. One of the most well-known side-effects of this medication is mild to moderate myalgia. Here, we report a case of a 49-year-old female with stage 3 breast cancers who developed severe acute myositis following docetaxel use. The mechanism of docetaxel-induced myositis remains unclear; however, physicians still need to be aware of the possibility of this complication in patients with cancer and a history of exposure to this medication.
多西他赛是一种抗微管药物，对局部晚期和转移性乳腺癌有高度疗效。多西他赛有几种不良反应，如骨髓抑制、周围神经病、体液潴留和乏力。这种药物最常见的副作用之一是轻到中度肌痛。在这里，我们报告了一例 49 岁女性，患有 3 期乳腺癌，在使用多西他赛后发生严重急性肌炎。多西他赛引起肌炎的机制尚不清楚；然而，医生仍需警惕癌症患者和有接触这种药物史的患者发生这种并发症的可能性。
