Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Thorac Cancer. 2022 Jul;13(14):2075-2077. doi: 10.1111/1759-7714.14480. Epub 2022 May 20.
Docetaxel is a cytotoxic taxane frequently used to treat patients with various cancers, including non-small cell lung cancer (NSCLC). Docetaxel is known to cause acute myalgias, arthralgias, and neuropathy, but there have been few published case reports of myositis. Here, we describe a rare case of docetaxel-induced myositis diagnosed based on laboratory data, thigh magnetic resonance imaging (MRI), and electromyography (EEG). A 66-year-old male was admitted for thigh pain and fatigue that onset 1 week prior. He had been diagnosed with stage IVA (cT4N0M1a) NSCLC 3 years ago and had been started on docetaxel (60 mg/m intravenously every 3 weeks; fourth-line chemotherapy) 1 month earlier. After the second cycle, he developed both thigh pain and fatigue. On admission, his creatinine phosphokinase (CPK) level was elevated, thigh MRI revealed diffuse muscle edema, and EEG showed myogenic changes. We found no plausible cause for myositis except docetaxel. He was diagnosed with myositis and treated with oral prednisolone. His symptoms were relieved and the CPK level declined. Although rare, this case indicates that clinicians should consider the possibility of myositis as a complication in patients on docetaxel.
多西他赛是一种细胞毒性紫杉烷类药物，常用于治疗包括非小细胞肺癌（NSCLC）在内的多种癌症。已知多西他赛可引起急性肌痛、关节痛和神经病，但少有肌炎的病例报告。在此，我们描述了一例罕见的基于实验室数据、大腿磁共振成像（MRI）和肌电图（EEG）诊断的多西他赛诱导性肌炎病例。一名 66 岁男性因大腿疼痛和疲劳入院，症状于 1 周前开始出现。他 3 年前被诊断为 IVA 期（cT4N0M1a）非小细胞肺癌，1 个月前开始接受多西他赛（60mg/m 静脉注射，每 3 周 1 次；四线化疗）治疗。第二次周期后，他出现了大腿疼痛和疲劳。入院时，他的肌酸磷酸激酶（CPK）水平升高，大腿 MRI 显示弥漫性肌肉水肿，EEG 显示肌源性改变。除了多西他赛，我们没有发现肌炎的其他合理病因。他被诊断为肌炎，并接受了口服泼尼松龙治疗。他的症状得到缓解，CPK 水平下降。虽然罕见，但该病例表明，临床医生应考虑多西他赛治疗患者发生肌炎的可能性。
