Department of Pathology, Cancer Centre Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Obstetrics and Gynaecology, Cancer Centre Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
BJOG. 2021 Feb;128(3):504-514. doi: 10.1111/1471-0528.16395. Epub 2020 Aug 9.
This paper briefly reviews the role of hypermethylation of host cell genes in cervical carcinogenesis and discusses potential clinical applications of methylation analysis in the management of high-risk HPV (hrHPV) -positive women. We argue that methylation assays can be used: 1. for primary triage of hrHPV-positive women to detect cervical cancer and advanced cervical intraepithelial neoplasia (CIN); 2. as secondary triage for women with minor cytological abnormalities to identify those with the highest risk of CIN3 or worse; 3. as exit test for women leaving the screening programme to identify cervical cancer and advanced CIN; and 4. to support management of CIN. TWEETABLE ABSTRACT: This paper discusses potential clinical applications of DNA methylation analysis in the management of women with a high-risk HPV infection.
本文简要回顾了宿主细胞基因甲基化在宫颈癌发生中的作用，并讨论了甲基化分析在管理高危型 HPV（hrHPV）阳性女性中的潜在临床应用。我们认为，甲基化检测可用于：1. 对 hrHPV 阳性女性进行初步分类，以检测宫颈癌和高级别宫颈上皮内瘤变（CIN）；2. 对细胞学异常较轻的女性进行二次分类，以确定具有最高 CIN3 及以上风险的女性；3. 作为筛查项目结束时用于识别宫颈癌和高级别 CIN 的检测；4. 支持 CIN 的管理。可发推文的摘要：本文讨论了 DNA 甲基化分析在管理高危型 HPV 感染女性中的潜在临床应用。
