Wang Jianhong, Xiao Xue, Yao Yuan
（ 610041） Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
（ 610000） Department of Gynecology, Chenghua District Maternal and Child Health Hospital, Chengdu 610000, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2025 Mar 20;56(2):571-576. doi: 10.12182/20250360403.
Cervical cancer (CC), a common malignant tumor afflicting women, poses serious threats to their health. Therefore, it is critical to develop a thorough understanding of the molecular mechanisms underlying the pathogenesis of CC, and to identify new therapeutic targets and methods for early diagnosis. The multi-omics research in tumors, involving proteomics, transcriptomics, genomics, microbiomics, and metabolomic, offers valuable insights. The multi-omics analysis of biological samples from patients with cervical intraepithelial neoplasia (CIN) and CC can help clarify the pathways involved in the pathogenesis and development of CC. Furthermore, multi-omics studies have identified a number of molecules associated with CC, including actin, lumican, family member with sequence similarity 83 (FAM83A), cadherin EGF-LAG seven-pass G-type receptor 3 (CELSR3), and 5,10-methylenetetrahydrofolate reductase (MTHFR), all of which show potential to be used as new biomarkers. These biomarkers will help make early diagnosis, improve the survival and prognosis of CC patients, and ultimately reduce CC incidence and mortality. This review synthesizes current advances in multi-omics research on cervical cancer.
宫颈癌（CC）是一种常见的女性恶性肿瘤，对女性健康构成严重威胁。因此，深入了解CC发病机制的分子机制，并确定早期诊断的新治疗靶点和方法至关重要。肿瘤的多组学研究，包括蛋白质组学、转录组学、基因组学、微生物组学和代谢组学，提供了有价值的见解。对宫颈上皮内瘤变（CIN）和CC患者的生物样本进行多组学分析，有助于阐明CC发病机制和发展过程中涉及的途径。此外，多组学研究已经确定了一些与CC相关的分子，包括肌动蛋白、核纤层蛋白、序列相似性家族83（FAM83A）、钙黏蛋白EGF-LAG七次跨膜G型受体3（CELSR3）和5,10-亚甲基四氢叶酸还原酶（MTHFR），所有这些分子都显示出作为新生物标志物的潜力。这些生物标志物将有助于早期诊断，提高CC患者的生存率和预后，并最终降低CC的发病率和死亡率。本综述综合了宫颈癌多组学研究的当前进展。
