VCA Canada - Alta Vista Animal Hospital, Ottawa, Ontario, Canada.
Department of Veterinary Clinical Science, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Vet Comp Oncol. 2021 Dec;19(4):724-734. doi: 10.1111/vco.12636. Epub 2020 Aug 11.
Perioperative administration of desmopressin has shown to significantly decrease rates of local recurrence and metastasis, and increase survival times in dogs with grade II and III mammary carcinomas. The objective of this study was to compare the oncologic outcome of cats with mammary carcinoma treated with bilateral mastectomy with or without perioperative administration of desmopressin. Medical records from nine veterinary institutions were searched to identify cats diagnosed with mammary carcinoma treated with bilateral mastectomy. Sixty cats treated with single-session or staged bilateral mastectomy were included. There were no significant differences in oncologic outcomes found between cats treated and not treated with desmopressin. No adverse effects were seen in any of the cats treated with perioperative desmopressin. Postoperative complications occurred in 18 cats (38.3%) treated with single-session bilateral mastectomy and in three cats (23.1%) treated with staged bilateral mastectomy (P = .48). Histologic grade and a modification of a proposed five-stage histologic staging system were both prognostic for disease-free interval. Incomplete histologic excision was associated with significantly increased rates of metastasis and tumour progression, and a shorter median survival time (MST). Cats that developed local recurrence also had a significantly shorter MST. The results of this study do not support the use of perioperative desmopressin to improve outcome when performing bilateral mastectomy for the treatment of mammary carcinoma in cats.
围手术期给予去氨加压素可显著降低 II 级和 III 级乳腺肿瘤犬的局部复发和转移率，并延长其生存时间。本研究的目的是比较行双侧乳房切除术且围手术期使用或不使用去氨加压素的猫的乳腺肿瘤的肿瘤学结果。通过检索 9 家兽医机构的病历，确定了接受双侧乳房切除术治疗的患有乳腺肿瘤的猫。共纳入 60 例接受单次或分期双侧乳房切除术治疗的猫。未发现去氨加压素治疗与未治疗的猫在肿瘤学结果方面存在差异。接受围手术期去氨加压素治疗的猫均未出现不良反应。行单次双侧乳房切除术的 18 只猫（38.3%）和分期双侧乳房切除术的 3 只猫（23.1%）出现了术后并发症（P=.48）。组织学分级和拟议的五阶段组织学分期系统的改良均是无病间隔的预后因素。不完全的组织学切除与转移和肿瘤进展的发生率显著增加以及中位生存时间（MST）显著缩短相关。发生局部复发的猫的 MST 也显著缩短。本研究结果不支持在猫行双侧乳房切除术治疗乳腺肿瘤时，使用围手术期去氨加压素来改善预后。
