School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
Curr Opin Struct Biol. 2020 Dec;65:51-60. doi: 10.1016/j.sbi.2020.05.012. Epub 2020 Jun 30.
Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.
迄今为止，已经报道了超过 5000 种卤代天然产物，其中许多来自海洋环境。卤素原子的引入可以显著影响分子的生物利用度和生物活性。最近，通过酶促卤化作用实现了后期的官能团化，包括选择性卤化和交叉偶联。卤化酶正成为越来越有价值的工具。本文综述了已发现的各种卤化酶，并从结构和机制的角度对其进行了考察，同时反映了卤化酶发现方面的许多最新进展。
