College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, China.
College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, China; College of Science, Hebei Agricultural University, Baoding 071001, China.
Food Chem. 2020 Dec 1;332:127427. doi: 10.1016/j.foodchem.2020.127427. Epub 2020 Jun 27.
A magnetic porous organic framework (M-POF) was rationally designed and served as a sorbent for magnetic solid-phase extraction of six nitroimidazoles from chicken meat prior to their assay by high-performance liquid chromatography with diode array detection. The M-POF exhibited good magnetic responsiveness and outstanding affinity to nitroimidazoles with large adsorption capacity up to 36 mg g. Under optimal conditions, the developed method offered good linearity (r greater than 0.992) in the range of 1.5-100.0 ng g, low limits of detection (S/N = 3) of 0.5-0.8 ng g, low limits of quantification of 1.5-2.5 ng g and high enrichment factors of 80-175 for the nitroimidazoles. The method was successfully applied to analyze nitroimidazoles in chicken meat. The recoveries were 80.2-118% with relative standard deviations lower than 12%. The adsorption mechanism was further explored and the results showed that the M-POF exhibited adsorption potential for compounds with strong polar interactions.
一种磁性多孔有机骨架（M-POF）被合理设计，并作为一种吸附剂，用于在高效液相色谱-二极管阵列检测法测定鸡肉中的六种硝基咪唑类药物之前，对其进行磁性固相萃取。M-POF 表现出良好的磁响应性和对硝基咪唑类药物的优异亲和力，其吸附容量高达 36mg/g。在最佳条件下，该方法在 1.5-100.0ng/g 的范围内具有良好的线性（r 大于 0.992），检测限（S/N=3）低至 0.5-0.8ng/g，定量限低至 1.5-2.5ng/g，富集因子高至 80-175。该方法成功地应用于分析鸡肉中的硝基咪唑类药物。回收率为 80.2-118%，相对标准偏差低于 12%。进一步探讨了吸附机制，结果表明，M-POF 对具有强极性相互作用的化合物表现出吸附潜力。
