Department of Cardiology, the First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China.
Department of Cardiology, the First Affiliated Hospital of Henan University of Science and Technology, Henan, China.
Am J Med Sci. 2020 Jul;360(1):50-54. doi: 10.1016/j.amjms.2020.03.022. Epub 2020 Apr 10.
Numerous studies have demonstrated that patients with non-O blood groups have a higher risk for venous thromboembolism than those with the O blood group. However, the effect of ABO blood groups on warfarin dose requirements in patients receiving anticoagulation in the Chinese Han population remains unknown. This study aimed to investigate the influence of ABO blood groups on warfarin dose requirements in a Chinese Han population.
A retrospective study was conducted in the First Affiliated Hospital of Shantou University Medical College in South China. Three hundred and fifty-eight patients with a confirmed diagnosis of deep vein thrombosis or atrial fibrillation were included. The frequency of blood groups and warfarin dose requirements were determined.
Of 358 patients with deep vein thrombosis or atrial fibrillation, 111 patients had blood group A (31.01%), 104 patients had blood group B (29.05%), 20 patients had blood group AB (5.59%) and 123 patients had blood group O (34.36%). The patients in the O blood group had lower warfarin dose requirements than those in the A, B and AB blood groups.
Our study showed that patients with non-O blood groups require higher doses of warfarin.
大量研究表明，非 O 型血患者发生静脉血栓栓塞的风险高于 O 型血患者。然而，ABO 血型对接受抗凝治疗的中国汉族人群华法林剂量需求的影响尚不清楚。本研究旨在探讨 ABO 血型对中国汉族人群华法林剂量需求的影响。
在中国南方汕头大学医学院第一附属医院进行了一项回顾性研究。共纳入 358 例深静脉血栓或心房颤动确诊患者。确定了血型的分布频率和华法林剂量需求。
在 358 例深静脉血栓或心房颤动患者中，111 例为 A 型血（31.01%），104 例为 B 型血（29.05%），20 例为 AB 型血（5.59%），123 例为 O 型血（34.36%）。与 A、B 和 AB 血型相比，O 型血患者的华法林剂量需求较低。
本研究表明，非 O 型血患者需要更高剂量的华法林。
