Department of Cardiology, Medical University of Graz, Graz, Austria.
Department of Cardiology, Medical University of Graz, Graz, Austria; BioTechMed Graz, Graz, Austria.
Prog Mol Biol Transl Sci. 2020;172:87-106. doi: 10.1016/bs.pmbts.2020.04.022. Epub 2020 May 12.
Autophagy is a cellular housekeeping and quality control mechanism that is essential for homeostasis and survival. By virtue of this role, any perturbations to the flow of this process in cardiac or vascular cells can elicit harmful effects on the cardiovascular system, and subsequently affect whole organismal health. In this chapter, we summarize the preclinical evidence supporting the role of autophagy in sustaining cardiovascular health during homeostasis and disease. Furthermore, we discuss how autophagy activation by dietary, genetic and pharmaceutical interventions can be exploited to counteract common cardiovascular disorders, including atherosclerosis, coronary artery disease, diabetic cardiomyopathy, arrhythmia, chemotherapy-induced cardiotoxicity and heart failure.
自噬是一种细胞内的自我维护和质量控制机制，对维持内环境稳定和生存至关重要。由于这种作用，任何对心脏或血管细胞中这一过程的流动的干扰都会对心血管系统产生有害影响，并随后影响整个机体的健康。在本章中，我们总结了支持自噬在维持内环境稳定和疾病期间心血管健康中的作用的临床前证据。此外，我们还讨论了如何通过饮食、遗传和药物干预激活自噬，以对抗常见的心血管疾病，包括动脉粥样硬化、冠状动脉疾病、糖尿病性心肌病、心律失常、化疗诱导的心脏毒性和心力衰竭。
