Kimball P M, Gamaz N, Sell S
Department of Pathology, University of Texas Health Science Center, Houston 77030.
Diabetes Res. 1988 Mar;7(3):113-6.
Immunomodulation with Cyclosporin may allow better management of the patient with insulin dependent diabetes mellitus. The cellular effects of CsA were determined on rabbit lymphocytes which are a resting (Go) population for which the kinetics of activation have been defined. Cyclosporin inhibited polyclonal T-cell activation as well as B-cell activation by T-dependent and T-independent antigens. Resting lymphocytes were the exclusive target of CsA. Primed or activated cells, as well as cells in G1, were resistant to the drug. Cyclosporin inhibited the generation of T-helper cells and spared suppressor cell generation. The inhibitory effects of cyclosporin were not reversible.
用环孢素进行免疫调节可能有助于更好地治疗胰岛素依赖型糖尿病患者。在兔淋巴细胞上测定了环孢素A（CsA）的细胞效应，兔淋巴细胞是静止（G0）群体，其激活动力学已明确。环孢素抑制多克隆T细胞激活以及由T细胞依赖性和T细胞非依赖性抗原引起的B细胞激活。静止淋巴细胞是环孢素A的唯一靶细胞。致敏或激活的细胞以及处于G1期的细胞对该药物具有抗性。环孢素抑制辅助性T细胞的产生，而保留抑制性T细胞的产生。环孢素的抑制作用是不可逆的。
