Bilal Jalal A, Malik Elfatih E, Al-Nafeesah Abdullah, Adam Ishag
Pediatrics Department, College of Medicine, Shaqra University, Shaqra, Saudi Arabia.
University of Khartoum, Box 102, Khartoum, Sudan.
Eur J Obstet Gynecol Reprod Biol. 2020 Sep;252:534-542. doi: 10.1016/j.ejogrb.2020.06.025. Epub 2020 Jun 15.
The aim of this systematic review and meta-analysis is to pool the prevalence of congenital malaria.
The guideline of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses was strictly followed. The published studies were searched in international and national databases. Quality assessment for studied was performed using the modified Newcastle - Ottawa scale. Pooled Meta logistic regression was computed using OpenMeta Analyst software. The heterogeneity was explored by the subgroup and meta-regression method.
Twenty-four studies enrolling 8148 newborns were conducted. All the studies were high-quality studies. The prevalence of congenital malaria ranged from 0.0 % in Colombia to 46.7 % in Nigeria. The overall prevalence of congenital malaria was 6.9 % (95 % CI: 4.8-7.9 %) (562/8148). There was large heterogeneity in prevalence of congenital malaria estimates among the different settings (I = 96.1 %). Hence the random effect model was used. In subgroup analyses, with respect to the type of malaria transmission, the prevalence of congenital malaria was significantly higher in areas characterized by unstable malaria transmission vs. the rate in areas with stable malaria transmission [16.8 % (95 % CI: 8.0-25.6 %) vs. 3.5 % (95 % CI: 2.3-4.6 %), Coefficient = 0.111; P = 0.035]. The results of additional sub- group (meta-regression) analyses showed a non-significant difference in prevalence of congenital malaria in study-sample sizes (Coefficient = -0.001, 95 % CI: -0.001 to 0.001), P-value = 0.534) and year of publication (C = -0.005; 95 % CI: -0.016 to 0.006), P-value = 0.369).
This meta-analysis showed a varied prevalence of congenital malaria across endemic areas and it was higher in areas with unstable malaria transmissions.
本系统评价和荟萃分析旨在汇总先天性疟疾的患病率。
严格遵循系统评价和荟萃分析的首选报告项目指南。在国际和国内数据库中检索已发表的研究。使用改良的纽卡斯尔-渥太华量表对研究进行质量评估。使用OpenMeta Analyst软件计算合并的Meta逻辑回归。通过亚组和Meta回归方法探讨异质性。
共纳入24项研究，涉及8148名新生儿。所有研究均为高质量研究。先天性疟疾的患病率在哥伦比亚为0.0%，在尼日利亚为46.7%。先天性疟疾的总体患病率为6.9%（95%CI：4.8-7.9%）（562/8148）。不同地区先天性疟疾患病率估计值存在较大异质性（I=96.1%）。因此采用随机效应模型。在亚组分析中，就疟疾传播类型而言，不稳定疟疾传播地区的先天性疟疾患病率显著高于稳定疟疾传播地区[16.8%（95%CI：8.0-25.6%）对3.5%（95%CI：2.3-4.6%），系数=0.111；P=0.035]。其他亚组（Meta回归）分析结果显示，研究样本量（系数=-0.001，95%CI：-0.001至0.001）和发表年份（C=-0.005；95%CI：-0.016至0.006）对先天性疟疾患病率的影响无显著差异，P值=0.534），P值=0.369）。
本荟萃分析显示，先天性疟疾在各流行地区的患病率各不相同，在疟疾传播不稳定的地区更高。
