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基于问卷(STOP-Bang与Dixon)的序贯模型以及夜间脉搏血氧饱和度监测对肥胖症患者行减重手术候选人阻塞性睡眠呼吸暂停筛查的敏感性。

Sensitivity of a sequential model based on a questionnaire (STOP-Bang vs Dixon) and nocturnal pulse oximetry for screening obstructive sleep apnea in patients with morbid obesity candidates for bariatric surgery.

作者信息

Lázaro Javier, Clavería Paloma, Cabrejas Carmen, Fernando José, Segura Silvia, Marín José M

机构信息

Servicio Neumología, Hospital Royo Villanova, Zaragoza, España.

Servicio Neumología, Hospital Royo Villanova, Zaragoza, España.

出版信息

Endocrinol Diabetes Nutr (Engl Ed). 2020 Oct;67(8):509-516. doi: 10.1016/j.endinu.2020.03.006. Epub 2020 Jun 30.

DOI:10.1016/j.endinu.2020.03.006
PMID:32620517
Abstract

INTRODUCTION

Obstructive sleep apnea (OSA) has a high incidence in patients with morbid obesity who are candidates for bariatric surgery (BS). Adequate screening would decrease the number of respiratory polygraphies (RPs).

OBJECTIVE

To analyze the value of a sequential model consisting of a questionnaire (modified Dixon [DXM] vs STOP-Bang) and nocturnal pulse oximetry in patients who were candidates for BS.

METHODS

A prospective study was conducted from July 1, 2014 to July 1, 2015 on candidates for BS, excluding those who have already undergone RP.

VARIABLES

questionnaires (Epworth, STOP-Bang, and DXM), anthropometric measurements, RP, and blood and gas tests. The sample was divided into patients with no or mild OSA (no OSA) and those with moderate to severe OSA (AHI>15).

RESULTS

A total of 70 patients were analyzed, 46 (65.7%) of them females. Moderate to severe OSA was diagnosed in 26 (37.1%) patients. STOP-Bang and DXM were compared using ROC curves, and greater area under the curve (AUC) was found for the latter (0.873 [0.74 -0.930] vs 0.781 [0.673-0.888]). STOP-Bang had greater sensitivity, 100%, as compared to 73.1% for DXM. ODI3% showed greater diagnostic yield (AUC=0.982 [0.970-1]). Use of the sequential model with STOP-Bang>3, DXM>5, and DXM>3 would have avoided 41 (58.5%), 50 (71.4%), and 41 (58.5%) RPs and 0, 7 (10%), and 0 false negatives, respectively.

CONCLUSION

Use of a sequential model based on the STOP-Bang and nocturnal pulse oximetry is a useful tool for screening OSA in patients with morbid obesity candidates for BS, decreasing the number of RPs.

摘要

引言

阻塞性睡眠呼吸暂停(OSA)在病态肥胖且适合进行减肥手术(BS)的患者中发病率很高。充分筛查可减少呼吸多导睡眠图(RP)的检查次数。

目的

分析由问卷(改良迪克森[DXM]与STOP - Bang)和夜间脉搏血氧饱和度测定组成的序贯模型在适合进行减肥手术的患者中的价值。

方法

于2014年7月1日至2015年7月1日对适合进行减肥手术的患者进行前瞻性研究,排除那些已经接受过呼吸多导睡眠图检查的患者。

变量

问卷(爱泼沃斯嗜睡量表、STOP - Bang和DXM)、人体测量、呼吸多导睡眠图检查以及血液和气体检测。样本分为无或轻度OSA(无OSA)患者和中度至重度OSA(呼吸暂停低通气指数>15)患者。

结果

共分析了70例患者,其中46例(65.7%)为女性。26例(37.1%)患者被诊断为中度至重度OSA。使用ROC曲线比较STOP - Bang和DXM,发现后者曲线下面积(AUC)更大(0.873[0.74 - 0.930]对0.781[0.673 - 0.888])。STOP - Bang的敏感性更高,为100%,而DXM为73.1%。氧减指数3%显示出更高的诊断效能(AUC = 0.982[0.970 - 1])。使用STOP - Bang>3、DXM>5和DXM>3的序贯模型分别可避免41次(58.5%)、50次(71.4%)和41次(58.5%)呼吸多导睡眠图检查,且假阴性分别为0、7次(10%)和0。

结论

基于STOP - Bang和夜间脉搏血氧饱和度测定的序贯模型是筛查适合进行减肥手术的病态肥胖患者中OSA的有用工具,可减少呼吸多导睡眠图检查次数。

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