Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Acad Radiol. 2021 Jul;28(7):963-968. doi: 10.1016/j.acra.2020.05.032. Epub 2020 Jun 30.
To analyze the association between mammographic features of microcalcifications and histopathological prognostic factors based on estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2/neu) in ductal carcinoma in situ (DCIS).
We retrospectively determined 66 patients with microcalcification-associated pure DCIS. Distribution and morphological features of the microcalcifications were described using Breast Imaging Reporting and Data System lexicon. All patients were divided into three subgroups: ER-positive, HER-2 positive, and triple-negative according to the immunohistochemical findings.
The morphological features of microcalcifications and receptor subtypes were significantly correlated (p = 0.026). Fine pleomorphic and fine linear branching microcalcifications were observed in 85.2% of HER-2 positive cases, whereas this ratio was 71.4 % in ER-positive and 25% in the triple-negative group. Fine linear branching microcalcifications with linear or segmental distribution were more frequently found with comedo necrosis (p < 0.05). Larger tumour sizes were also associated with microcalcification distribution (p < 0.001). Segmental microcalcifications more likely associated with larger tumour sizes.
Mammographic features in DCIS correlated with immunohistochemical and histopathological prognostic factors.
分析乳腺原位癌（DCIS）中微钙化的钼靶特征与雌激素受体（ER）和人表皮生长因子受体 2（HER2/neu）的组织病理学预后因素之间的关系。
我们回顾性分析了 66 例微钙化相关的纯 DCIS 患者。采用乳腺影像报告和数据系统（BI-RADS）词汇描述微钙化的分布和形态特征。根据免疫组化结果，所有患者分为 ER 阳性、HER2 阳性和三阴性三组。
微钙化的形态特征与受体亚型显著相关（p=0.026）。HER2 阳性病例中，细多形性和细线性分支微钙化占 85.2%，而 ER 阳性组为 71.4%，三阴性组为 25%。伴有粉刺样坏死的微钙化更常表现为线性或节段性分布（p<0.05）。较大的肿瘤大小也与微钙化分布相关（p<0.001）。节段性微钙化更可能与较大的肿瘤大小相关。
DCIS 的钼靶特征与免疫组化和组织病理学预后因素相关。
