考虑 HPV 状态的口咽鳞状细胞癌中 PD-L1 表达的综合分析及其临床意义。
Comprehensive Analysis and Clinical Implication of PD-L1 Expression Considering HPV Status in Oropharyngeal Squamous Cell Carcinoma.
机构信息
Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
Department of Pathology, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
出版信息
Anticancer Res. 2020 Jul;40(7):4001-4010. doi: 10.21873/anticanres.14394.
BACKGROUND/AIM: This study was conducted to comprehensively evaluate programmed cell death ligand 1 (PD-L1) expression, and analyze the clinical and prognostic implications of PD-L1 expression in oropharyngeal squamous cell carcinoma (OPSCC).
PATIENTS AND METHODS
We evaluated the expression of PD-L1 using the antibodies SP263 and SP142 in 106 patients with OPSCC, using immunohistochemistry. PD-L1 expression was subdivided into tumor cell score (TC), immune cell score (IC), and combined score (CS). Correlations between each PD-L1 expression and HPV status, clinicopathological features, and survival were analyzed.
RESULTS
The expression levels of PD-L1 SP263 and SP142 were significantly correlated. High PD-L1 SP263 TC and CS and SP142 IC and CS were associated with HPV positivity. PD-L1 expression showed no effect on survival in all patients' group. However, in the subgroup analysis, high TC and CS of both PD-L1 SP263 and SP142 were correlated with shorter time to recurrence in the HPV positive group.
CONCLUSION
High expression of PD-L1 was associated with HPV positivity in OPSCC. In addition, high expression of PD-L1 might suggest a poorer outcome, especially in the HPV positive subgroup. PD-L1 could be a useful predictive and prognostic biomarker in OPSCC.
背景/目的：本研究旨在全面评估程序性死亡配体 1（PD-L1）在口咽鳞状细胞癌（OPSCC）中的表达，并分析 PD-L1 表达的临床和预后意义。
患者和方法
我们使用免疫组织化学方法，用 SP263 和 SP142 抗体评估了 106 例 OPSCC 患者的 PD-L1 表达情况。将 PD-L1 表达分为肿瘤细胞评分（TC）、免疫细胞评分（IC）和联合评分（CS）。分析了每种 PD-L1 表达与 HPV 状态、临床病理特征和生存之间的相关性。
结果
PD-L1 SP263 和 SP142 的表达水平呈显著相关。高 PD-L1 SP263 TC 和 CS 以及 SP142 IC 和 CS 与 HPV 阳性相关。PD-L1 表达在所有患者组中均与生存无关。然而，在亚组分析中，PD-L1 SP263 和 SP142 的 TC 和 CS 高与 HPV 阳性组的复发时间较短相关。
结论
OPSCC 中 PD-L1 的高表达与 HPV 阳性相关。此外，PD-L1 的高表达可能提示预后较差，尤其是在 HPV 阳性亚组中。PD-L1 可能是 OPSCC 中一种有用的预测和预后生物标志物。
Zotero 插件