老年营养风险指数对结直肠肝转移同步患者预后的影响。
Prognostic Impact of Geriatric Nutritional Risk Index in Patients With Synchronous Colorectal Liver Metastasis.
机构信息
Department of Hepato-Biliary Pancreatic Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Anticancer Res. 2020 Jul;40(7):4165-4171. doi: 10.21873/anticanres.14416.
BACKGROUND/AIM: The Geriatric Nutritional Risk Index (GNRI) is a prognostic indicator for several cancers; however, the association between the GNRI and colorectal liver metastasis (CRLM) remains unknown.
PATIENTS AND METHODS
Eighty patients who underwent hepatectomy for synchronous CRLM were divided into two groups based on the GNRI.
RESULTS
The preoperative CA19-9 levels were significantly higher in the low (GNRI ≤98; n=30) than the normal GNRI group (GNRI >98; n=50). Patients in the low GNRI group had poorer outcomes than those in the normal GNRI group. A low GNRI was an independent prognostic factor for recurrence-free survival and overall survival. Among 50 patients who experienced recurrence, only 16 of 22 patients (72.7%) in the low GNRI group could receive intensive treatment and 27 of 28 patients (96.4%) in the normal GNRI group.
CONCLUSION
The GNRI is a simplified prognostic factor for patients with CRLM.
背景/目的：老年营养风险指数（GNRI）是多种癌症的预后指标；然而，GNRI 与结直肠癌肝转移（CRLM）之间的关系尚不清楚。
患者与方法
80 名接受同步 CRLM 肝切除术的患者根据 GNRI 分为两组。
结果
低 GNRI（GNRI≤98；n=30）组患者的术前 CA19-9 水平明显高于正常 GNRI 组（GNRI＞98；n=50）。低 GNRI 组患者的预后较正常 GNRI 组差。低 GNRI 是无复发生存和总生存的独立预后因素。在 50 例复发患者中，低 GNRI 组仅 22 例患者中的 16 例（72.7%）能够接受强化治疗，正常 GNRI 组 28 例患者中的 27 例（96.4%）。
结论
GNRI 是 CRLM 患者的简化预后因素。
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